PMID: 9660307Jul 11, 1998Paper

Modulation of the insulin-like growth factor system by chronic alcohol feeding

Alcoholism, Clinical and Experimental Research
C H LangK H McDonough

Abstract

Insulin-like growth factor (IGF)-I is a potent anabolic agent that plays an important role in regulating muscle protein balance. Alterations in one or more of the various components of the IGF system may be in part responsible for the muscle wasting that accompanies chronic alcohol consumption. The purpose of the present study was to characterize changes in the growth hormone-IGF axis produced by chronic alcohol consumption in rats. After 8 weeks of alcohol feeding, the IGF-I concentration was decreased in plasma (31%) as well as in the liver and skeletal muscle (40-50%), compared with pair-fed control animals. In addition, alcohol consumption decreased IGF-I mRNA abundance in liver and muscle (approximately 50%). IGF-I content in duodenum and kidney, however, was not altered by alcohol feeding. Concomitantly, the relative concentration of IGF binding protein (IGFBP)-1 was increased in plasma, liver, and muscle of alcohol-fed rats, compared with control values. In contrast, no changes in the plasma concentrations of IGFBP-2, -3, or -4 were detected in alcohol-fed rats at this time point Previous studies have indicated that elevations in glucocorticoids or decreases in insulin or growth hormone might be responsible for the decre...Continue Reading

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Citations

Jun 29, 2005·The International Journal of Biochemistry & Cell Biology·Charles H LangThomas C Vary
Jun 1, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H GrønbaekH Hey
Jun 22, 2001·Drug and Alcohol Dependence·V R PreedyT J Peters
Mar 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jun RenHolly M Brown-Borg
May 2, 2001·The International Journal of Biochemistry & Cell Biology·C H LangT C Vary
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ing-Marie JonssonAndrej Tarkowski
Aug 21, 2014·BioMed Research International·Yuan LiWen-Xing Ding
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·Nadia Rachdaoui, Dipak K Sarkar
Sep 7, 2012·Journal of Pharmacological and Toxicological Methods·Daniel R ShardaDonna H Korzick
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Robert A Frost, Charles H Lang
Jul 21, 2007·Journal of Hepatology·Laurent MagneMichèle Garlatti
May 12, 2009·Alcoholism, Clinical and Experimental Research·Jeffrey S Otis, David M Guidot
Jun 15, 2007·Alcoholism, Clinical and Experimental Research·Martin J J RonisJan Calissendorff
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Joaquim Fernandez-SolàAlvaro Urbano-Márquez
Aug 2, 2005·Alcohol·Xiang-Dong Wang
Nov 22, 2007·Alcoholism, Clinical and Experimental Research·Thomas C VaryRachel Lantry
Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Patricia E MolinaJames M Crawford
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Thomas C VaryCharles H Lang
Jan 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Mezey
Aug 22, 2018·Annual Review of Nutrition·Scot R Kimball, Charles H Lang
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·M PassiltaY A Kesäniemi
May 19, 2010·Alcoholism, Clinical and Experimental Research·Rachel L FogleThomas C Vary
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·D K SarkarK W Singletary
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Patricia E MolinaManuela Neuman
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·N V EmanueleM A Emanuele
May 24, 2001·Alcoholism, Clinical and Experimental Research·S A LynchS N Pennington
Dec 25, 2002·Alcoholism, Clinical and Experimental Research·Thomas C VaryCharles H Lang
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas C VaryAndrew Sumner

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