PMID: 9550221Apr 29, 1998Paper

Modulation of the motility of the vagina vera of Ascaris suum in vitro by FMRF amide-related peptides

Parasitology
R A FellowesD W Halton

Abstract

Ascaris suum contains a large number of FMRFamide-related peptides (FaRPs) of which KNEFIRFamide (AF1), KHEYLRFamide (AF2) and KSAYMRFamide (AF8, also called PF3) have been extensively studied and are known to exert actions on somatic muscle strips of the worm. In the present study, the effects of AF1, AF2 and AF8 on the activity of the vagina vera of female A. suum have been examined in vitro. The vagina vera is a muscular tube connecting the uterus and vagina uteri to the gonopore and is probably involved in regulating egg output. The tissue exhibited spontaneous, rhythmic contractions in vitro, which were modulated by each of the FaRPs tested. The effects of each of the peptides were qualitatively and quantitatively different, and in each case were reversible. AF1 (1 microM) caused a biphasic response in the form of a transient lengthening of the preparation, followed by a shortening; contractions were initially inhibited but resumed 5 min post-addition of the peptide. Lower concentrations (< or = 0.1 microM) induced a less marked effect, with rhythmic contractions returning 5 min post-addition. AF2 and AF8 reduced contraction frequency at concentrations > or = 0.1 microM. Both peptides also caused the tissue to shorten, alt...Continue Reading

Citations

Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Mar 10, 2004·Micron : the International Research and Review Journal for Microscopy·David W Halton
Jul 16, 2002·International Journal for Parasitology·Michael J KimberAaron G Maule
Mar 14, 2003·International Journal for Parasitology·D P ThompsonT G Geary
Mar 24, 1999·Trends in Neurosciences·D J Brownlee, I Fairweather
Aug 28, 2001·Molecular and Biochemical Parasitology·M J KimberA G Maule
Oct 22, 2009·Journal of Helminthology·M J G JohnstonA G Maule
Apr 29, 2011·Journal of Proteome Research·Jessica L JareckiAntony O Stretton
Feb 17, 2000·Annals of the New York Academy of Sciences·T G GearyD P Thompson
Feb 17, 2000·Annals of the New York Academy of Sciences·D J Brownlee, R J Walker
Sep 27, 2008·WormBook : the Online Review of C. Elegans Biology·Chris Li, Kyuhyung Kim
Dec 24, 2013·Developmental and Comparative Immunology·Surakasi Venkata PrasadYonggyun Kim
Jun 20, 2000·Journal of Neurogenetics·R NicholsC Rosario
Jul 8, 2008·International Journal for Parasitology·Paul McVeighAaron G Maule
Apr 28, 2004·International Journal for Parasitology·Angela MousleyAaron G Maule
Jul 11, 2006·Trends in Parasitology·Paul McVeighAaron G Maule
Apr 8, 2006·International Journal for Parasitology·Paul McVeighAaron G Maule
Sep 28, 2005·International Journal for Parasitology·Angela MousleyNikki J Marks
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Paul McVeighAaron G Maule
Jul 24, 1998·Biochemical and Biophysical Research Communications·N J MarksC Shaw
Oct 30, 2014·Frontiers in Endocrinology·Chris Li, Kyuhyung Kim
Feb 28, 2017·PLoS Pathogens·Neil D WarnockJohnathan J Dalzell
Aug 5, 2021·ACS Chemical Neuroscience·Louise E AtkinsonAngela Mousley
Aug 28, 2021·International Journal for Parasitology·Fiona M McKayAngela Mousley

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