Modulation of the peripheral blood transcriptome by the ingestion of probiotic yoghurt and acidified milk in healthy, young men

PloS One
Kathryn J BurtonGuy Vergères

Abstract

The metabolic health benefits of fermented milks have already been investigated using clinical biomarkers but the development of transcriptomic analytics in blood offers an alternative approach that may help to sensitively characterise such effects. We aimed to assess the effects of probiotic yoghurt intake, compared to non-fermented, acidified milk intake, on clinical biomarkers and gene expression in peripheral blood. To this end, a randomised, crossover study was conducted in fourteen healthy, young men to test the two dairy products. For a subset of seven subjects, RNA sequencing was used to measure gene expression in blood collected during postprandial tests and after two weeks daily intake. We found that the postprandial response in insulin was different for probiotic yoghurt as compared to that of acidified milk. Moreover changes in several clinical biomarkers were associated with changes in the expression of genes representing six metabolic genesets. Assessment of the postprandial effects of each dairy product on gene expression by geneset enrichment analysis revealed significant, similar modulation of inflammatory and glycolytic genes after both probiotic yoghurt and acidified milk intake, although distinct kinetic cha...Continue Reading

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Citations

Feb 6, 2019·The American Journal of Clinical Nutrition·Nathalie VionnetGuy Vergères
Sep 2, 2020·Journal of the American College of Nutrition·Kristin M NiemanChristopher J Cifelli
May 23, 2018·The Journal of Nutrition·Grégory PimentelGuy Vergères
Jul 29, 2020·Nutrients·Jolana Wagner-SkacelSusanne Bengesser
Nov 20, 2018·Nutrition Reviews·Melissa Anne Fernandez, André Marette
Nov 20, 2018·Nutrition Reviews·Car Reen Kok, Robert Hutkins
Sep 27, 2019·Advances in Nutrition·Kristin M HirahatakeSean H Adams
Jan 7, 2021·Current Nutrition Reports·Leila Khorraminezhad, Iwona Rudkowska
Feb 6, 2019·Food Research International·Ju Young EorSae Hun Kim
Dec 17, 2020·Molecular Nutrition & Food Research·Kathryn J Burton-PimentelGuy Vergères
Feb 2, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rochelle DavisCatherine E Huggins
Feb 25, 2021·Advances in Nutrition·Despoina Eugenia KiousiAlex Galanis

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Datasets Mentioned

BETA
GSE98645

Methods Mentioned

BETA
GTPase

Clinical Trials Mentioned

NCT02230345

Software Mentioned

CellMix
Real Time Analysis
BioMart
nextgen
Ensembl
R
cutadapt
edgeR
MESS package
Adaptive Visual Analogue Scale

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