Modulation of the QT interval duration in hypertension with antihypertensive treatment

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Jan KlimasSimon W Rabkin

Abstract

The duration of the QT interval as measured by 12-lead electrocardiography is a measure of myocardial repolarization and is widely used to describe cardiac abnormalities, to determine the presence of cardiac toxicity and to evaluate drug safety. In hypertension, the QT interval is a predictor of the risk of both coronary events and cardiovascular death, after adjusting for the effects of additional risk factors. The mechanism of QT interval prolongation is multifactorial and includes cardiomyocyte hypertrophy and increased left ventricular mass, with accompanying changes in left ventricular transmural dispersion of repolarization, as well as changes in the tone of the autonomic nervous system of some patients with hypertension and mechano-electrical feedback, although this mechanism is less likely. Antihypertensive drugs vary in their effect on QT interval duration. The mechanisms underlying their effect depend on changes in left ventricular mass and autonomic nervous system tone, as well as changes in the activity of cardiac ion channels. Although blood pressure reduction is the primary goal of antihypertensive drug therapy and although the choice of antihypertensive drug treatment regimens varies among different individuals, ...Continue Reading

References

Jul 1, 1978·Stroke; a Journal of Cerebral Circulation·S W RabkinR B Tate
Oct 1, 1990·The American Journal of Cardiology·C Funck-BrentanoP Jaillon
Jun 1, 1990·British Heart Journal·C P DayR W Campbell
Sep 1, 1989·Journal of Cardiovascular Pharmacology·L M van WijkK I Lie
May 1, 1986·American Heart Journal·J ManouvrierG Ducloux
Nov 15, 1985·The American Journal of Cardiology·M RomanoM Chiariello
Oct 1, 1980·British Journal of Pharmacology·A E Raine, E M Vaughan Williams
Mar 1, 1984·European Heart Journal·J I Robertson
Jul 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·L LindS Ljunghall
Nov 1, 1996·Hypertension·J MayetS A Thom
Feb 1, 1997·The Journal of General Physiology·V AvdoninT Hoshi
Jan 1, 1997·European Heart Journal·P Hjemdahl, N H Wallén
Dec 17, 1997·The American Journal of Cardiology·E Grossman, F H Messerli
May 20, 1998·The American Journal of Cardiology·J R González-JuanateyM G de la Peña
Jun 6, 1998·Cardiovascular Research·G Hasenfuss
Aug 26, 1998·Circulation·M SuzukiM Hiraoka
Feb 19, 1999·Hypertension·P O LimT M MacDonald
Mar 18, 1999·The American Journal of Cardiology·L FauchierJ P Fauchier
Oct 26, 1999·Cardiovascular Research·G F Tomaselli, E Marbán
Jan 5, 2000·American Journal of Hypertension·F H Messerli
Jun 13, 2000·Japanese Heart Journal·A H Kaftan, O Kaftan
Jun 16, 2000·Diabetologia·R MarfellaD Giugliano

❮ Previous
Next ❯

Citations

Nov 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mortimer Gierthmuehlen, Dennis T T Plachta
Jun 5, 2016·Cardiac Electrophysiology Clinics·Vincent Algalarrondo, Stanley Nattel
Apr 17, 2016·European Journal of Clinical Pharmacology·Thomas H LangenickelIris Rajman
Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mihály RuppertGábor Szabó
Apr 7, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sandor Batkai, Ariana Foinquinos
Jul 14, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·T SatoT Miura
Dec 28, 2019·Renal Failure·Peng LiuGuoliang Li
Oct 30, 2019·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ahmed E GaafarMohamed El Kassas
Apr 29, 2021·International Journal of General Medicine·Olutoyin Morenike LawalFolajimi Otubogun
May 30, 2021·Critical Reviews in Oncology/hematology·Stefano FogliRomano Danesi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.