Modulation of the response to estradiol-17beta of rat vascular tissues by a non calcemic vitamin D analog

The Journal of Steroid Biochemistry and Molecular Biology
Dalia SomjenG H Posner

Abstract

Estradiol-17beta (E(2)) increases creatine kinase (CK) specific activity in aorta (Ao) and left ventricle of the heart (Lv) from rat females. In the present study, we analyzed the effects of pretreatment with the non calcemic analog of vitamin D, JK 1624 F2-2 (JKF) on the response to E(2) (either 0.5 or 5 microg/rat) of Ao and Lv from prepubertal female rats. JKF did not affect CK in either organ. However, pretreatment with JKF (0.1 ng/g body weight for 1 or 2 weeks) increased the CK response to E(2) (0.5 microg/rat) by 50 +/- 10% in Ao and by 150 +/- 12% in Lv. The CK response to 5 microg/rat of E(2) in intact female rats, was increased by 118 +/- 15% and 99 +/- 11% in the Ao and by 89 +/- 6% and 112 +/- 13% in the Lv, in animals treated daily with JKF for 1 or 2 weeks, respectively, before administration of E(2). JKF also increased the response to 500 microg/rat raloxifene (Ral) by 47 +/- 8% in Ao and by 56 +/- 12% in Lv. Preliminary experiments showed that JKF treatment induced a approximately 50% increase in estradiol receptor ERalpha in both organs. The results indicate that the vitamin D analog JKF upregulates the response and sensitivity of vascular tissues to E(2), in association with increased expression of their ERalp...Continue Reading

References

Sep 1, 1991·Atherosclerosis·M Seed
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D SömjenA M Kaye
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D A ShewmonS Baker
Jan 1, 1997·Fertility and Sterility·E K HonoréT B Clarkson
Dec 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·D SömjenA M Kaye
May 12, 2000·Journal of the American College of Cardiology·L W Lissin, J P Cooke
Mar 19, 2003·The New England Journal of Medicine·Jennifer HaysUNKNOWN Women's Health Initiative Investigators

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Citations

Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Pandu R GangulaDiane Moseberry
Oct 13, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Dalia SomjenNaftali Stern

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