Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245

Pharmacology, Biochemistry, and Behavior
Manik R PullagurlaRichard A Glennon

Abstract

5-HT(6) serotonin receptors are distributed within some dopamine terminal regions in the brain leading to suggestions that they might influence dopaminergic function. In the present study, the 5-HT(6) antagonist 5-methoxy-N,N-dimethyl-N(1)-benzenesulfonyltryptamine (MS-245) was without effect when administered (3.0-7.5 mg/kg) to rats trained to discriminate (+)amphetamine (1.0 mg/kg) from saline vehicle in a two-lever drug discrimination task. Administered in combination, 0.3 mg/kg (i.e., the ED(50) dose) of (+)amphetamine plus 5.0 mg/kg of MS-245 elicited 95% amphetamine-appropriate responding. Similar studies were conducted using rats trained to discriminate cocaine (8.0 mg/kg) from saline vehicle, but a combination of 2.0 mg/kg (i.e., the ED(50) dose) of cocaine together with relatively low doses of MS-245 resulted in the percent response (approximately 50%) expected from administration of this dose of cocaine or in disruption of the animals' behavior. The present results confirm findings from other laboratories that 5-HT(6) antagonists can modulate amphetamine-induced behavioral actions, and further extend these findings to an example of a different structural class of 5-HT(6) antagonists and to a different behavioral parad...Continue Reading

References

Sep 17, 1991·European Journal of Pharmacology·L J FurmidgeD Clark
Jan 31, 1989·European Journal of Pharmacology·E B NielsenP H Andersen
Jan 1, 1986·Medicinal Research Reviews·R Young, R A Glennon
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Jun 8, 2002·Current Topics in Medicinal Chemistry·Michael G N Russell, Rebecca Dias
May 28, 2003·Psychopharmacology·Elizabeth E ElliotJonathan L Katz

❮ Previous
Next ❯

Citations

May 12, 2010·Addiction Biology·Małgorzata FilipEdmund Przegaliński
Feb 1, 2008·European Journal of Pharmacology·Anna Wesołowska, Agnieszka Nikiforuk
Jan 13, 2006·Trends in Pharmacological Sciences·Christian P Müller, Joseph P Huston
Jul 12, 2005·Pharmacology & Therapeutics·Ellen S Mitchell, John F Neumaier
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Jul 13, 2007·Bioorganic & Medicinal Chemistry·Hassan ElokdahLee E Schechter
Jan 29, 2011·Pharmacological Reports : PR·Katarzyna FijałMałgorzata Filip
Jul 11, 2009·Expert Review of Neurotherapeutics·Werner J Geldenhuys, Cornelis J Van der Schyf
Oct 12, 2010·Journal of Medicinal Chemistry·Kevin G LiuThomas A Comery
Dec 7, 2007·Bioorganic & Medicinal Chemistry Letters·Churl Min SeongNo Sang Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.