Modulation of the stimulus effects of morphine by d-amphetamine

Pharmacology, Biochemistry, and Behavior
M GaiardiM Babbini

Abstract

The stimulus effects of morphine and d-amphetamine coadministration were studied in rats. Place conditioning, drug discrimination, and taste conditioning were employed to assess the rewarding, discriminative, and aversive stimulus properties of both drugs. d-Amphetamine increased the rewarding and morphine-like discriminative stimulus effects of 1.25 mg/kg morphine. d-Amphetamine did not, however, change the aversive effects of 1.25 mg/kg morphine, or any effect of higher (5-20 mg/kg) morphine doses. Because the rewarding/discriminative properties and the aversive properties of a drug are considered the main attributes that regulate (facilitate and weaken, respectively) drug-seeking behavior, the present data are in keeping with clinical reports indicating that amphetamines are sometimes used by opiate abusers in an attempt to increase the effect obtained from poor-quality heroin.

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Citations

Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·A L Riley, G R Simpson
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Nov 17, 2001·Behavioural Pharmacology·M GaiardiM Bartoletti
Jan 18, 2006·Pharmacology, Biochemistry, and Behavior·Karen A PescatoreAnthony L Riley
Sep 13, 2005·Pharmacology, Biochemistry, and Behavior·Gregory D BusseAnthony L Riley
Aug 18, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M BartolettiM Gaiardi
Nov 5, 2019·Pharmacology, Biochemistry, and Behavior·Anthony L RileyKaren A Pescatore

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