Modulation of the systemic inflammatory response by recombinant human interleukin-11: a prospective randomized placebo controlled clinical study in patients with hematological malignancy

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Michael EllisBasel K al-Ramadi

Abstract

The immunomodulatory activities of recombinant human interleukin-11 (rhIL-11) were investigated in a clinical trial among patients with hematological malignancy, randomized to either rhIL-11 or placebo throughout chemotherapy. Daily serum concentrations of sTNFRI, IL-6, IL-8, TNFalpha, and CRP were measured. Higher sTNFRI levels [mean pg/ml (95% CI)] were detected in patients receiving rhIL-11 compared to placebo [1749.7 (1626-1882.9) versus 1038.5 (953.3-1131.3)] respectively (P = 0.01) for all 898 observations and during febrile days [2327.6 (2142.6-2528.2) versus 1308.9 (1163-1473.2), P = 0.12] and during days without infection [1406.6 (1266.1-1563) versus 871.3 (774.9-979.6), P < 0.001]. A similar pattern in CRP concentrations was observed. Multivariate analysis indicated rhIL-11 was associated with elevated sTNFRI or CRP independent of infectious episodes and other factors. 7 patients (all receiving placebo) of 40 had elevated TNFalpha levels. IL-6 and IL-8 levels were not substantially affected by rhIL-11. Bacteremia, fungal infections, and fever of unknown origin (FUO) were reduced in rhIL-11-treated patients. Given the role of sTNFRI in dampening the deleterious effects of a hyperactive TNFalpha environment, rhIL-11-ind...Continue Reading

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Citations

Jul 12, 2008·American Journal of Respiratory Cell and Molecular Biology·Chun Geun LeeJack A Elias
Mar 28, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ricardo Bizogne SoutoSérgio Luiz Dalmora
Aug 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuanli RenHui Chen
Sep 19, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Yuri KheifetzZvia Agur
Jan 31, 2016·Cancer Letters·Dixon H XuYujiang Fang
May 1, 2007·Immunology Letters·M Margarida Souto-Carneiro, Moncef Zouali
Oct 8, 2008·Annals of the New York Academy of Sciences·Michael Ellis
Nov 24, 2016·Inflammation·Maryam BoshtamHossein Khanahmad
Jul 9, 2010·Journal of Leukocyte Biology·Tracy Putoczki, Matthias Ernst
Jun 20, 2008·Nature Immunology·Basel al-RamadiWilhelm Schwaeble
Aug 26, 2014·Reproduction, Fertility, and Development·Amy WinshipEvdokia Dimitriadis

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