Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne

Dermato-endocrinology
Marco RochaEdileia Bagatin

Abstract

Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris.Propionibacterium acnesis recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through theNFκB pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Two treatments were performed over six months: 15% azelaic acid gel (AA) bid (n = 18) and oral contraceptive (COC) drospirenone 3 mg/ethinylestradiol .02 mg (n = 20). Biopsies were taken at baseline (control, lesion, perilesional) and at the conclusion (lesion and perilesional) of the study to evaluate TLR-2 expression by immunohistochemistry. Lesion count and blind photographic evaluation were used for efficacy. The groups were homogeneous: 70% of lesions were located in the submandibular area, 95% of participants had inflammatory lesions; of these, 50% had persistent and 50% had late-onset acne. The mean ages were 33.7 ± 5.5 and 33.1 ± 5.3 years (COC and AA group, respectively). A moderate clinical improvem...Continue Reading

References

May 19, 2004·Archives of Dermatological Research·Andor PivarcsiLajos Kemény
Jan 22, 2005·The Journal of Physiology·Graeme I LancasterMichael Gleeson
Jun 29, 2005·The Journal of Investigative Dermatology·Jamie E McInturffJenny Kim
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Jenny Kim
Nov 26, 2005·The British Journal of Dermatology·S JugeauB Dreno
Sep 30, 2006·American Journal of Clinical Dermatology·Christina Williams, Alison M Layton
Oct 20, 2007·Journal of the American Academy of Dermatology·Christin N CollierBoni E Elewski
Mar 11, 2008·La Presse médicale·Gwenaelle Dumont-Wallon, Brigitte Dréno
Jun 27, 2009·Experimental Dermatology·Ichiro KurokawaChristos C Zouboulis
Jan 20, 2010·Clinics in Dermatology·Andreas D Katsambas, Clio Dessinioti
Mar 13, 2010·Dermato-endocrinology·Christos C Zouboulis
Jun 16, 2010·Experimental Dermatology·Arianna MastrofrancescoMauro Picardo
Jul 14, 2010·Journal of the American Academy of Dermatology·Bruno CapitanioChristos C Zouboulis
Jul 28, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·C W ChoiS W Youn
May 26, 2011·European Journal of Dermatology : EJD·Marisa TaylorRebecca Porter
Aug 19, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·S Preneau, B Dreno
Apr 20, 2012·The Journal of Investigative Dermatology·Melanie C DispenzaDiane M Thiboutot
Apr 25, 2012·Obstetrics and Gynecology·Elizabeth G RaymondEve Espey
Jun 15, 2012·The Cochrane Database of Systematic Reviews·Ayodele O ArowojoluDavid A Grimes
Dec 6, 2012·The British Journal of Dermatology·K Bhate, H C Williams
Jan 11, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoJ C Harper
Jan 22, 2013·Journal of the American Academy of Dermatology·Kelly H Tyler, Matthew J Zirwas
Apr 27, 2013·Indian Journal of Dermatology, Venereology and Leprology·Chembolli Lakshmi
Sep 10, 2013·BMC Dermatology·Joanne Louise SelwayKenneth Langlands
Dec 7, 2013·Skin Pharmacology and Physiology·R Holzmann, K Shakery
Jan 16, 2014·The Journal of Investigative Dermatology·Diane M ThiboutotE Anne Eady
Jun 10, 2014·Inflammation & Allergy Drug Targets·Marco Alexandre RochaEdileia Bagatin
Jun 22, 2014·Archives of Dermatological Research·R G R AlbuquerqueM L Andersen
Oct 10, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoUNKNOWN Global Alliance to Improve Outcomes in Acne
Dec 9, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·N AuffretB Dréno
Dec 24, 2015·Cutaneous and Ocular Toxicology·Emin OzluNecmettin Akdeniz
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
Dec 28, 2016·International Journal of Medical Microbiology : IJMM·Qi SuGünther Weindl
Jan 14, 2017·Expert Opinion on Pharmacotherapy·Nora VeraSteven R Feldman

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Citations

Jul 31, 2020·The Journal of Dermatological Treatment·Tamara SearleFiras Al-Niaimi
Aug 4, 2020·Expert Review of Clinical Pharmacology·Edileia Bagatin, Caroline Sousa Costa
May 8, 2021·Expert Review of Clinical Pharmacology·Edileia BagatinCaroline Sousa Costa

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BETA
biopsies
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