Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection.

Mediators of Inflammation
Louise E PilsburyMartin Vordermeier

Abstract

Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. Here we describe the LILR family, their inhibitory effect on TLR activity in cells of the monocytic lineage, their signalling pathway, and their antimicrobial effects during bacterial infection. Agents have already been identified which enhances or inhibits LILR activity raising the future possibility that modulation of LILR function could be used as a means to modulate TLR activity.

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Citations

Mar 7, 2012·Immunologic Research·Tanja DzopalicMiodrag Colic
Apr 10, 2012·PloS One·Louise HoganRachel L Allen
Oct 27, 2015·Immunological Reviews·Adam TaylorSuresh Mahalingam
Aug 10, 2016·Frontiers in Immunology·Laura Emily Hudson, Rachel Louise Allen
May 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sang-Min LeeWon-Ha Lee
Jun 18, 2019·BioMed Research International·Yinghao Yu, Jijun Zhao
Jun 30, 2019·The Journal of Infectious Diseases·Siqi MingXi Huang

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