Modulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 protein.

Virology
Catherine C CruzM T Heise

Abstract

Alphaviruses are mosquito-borne viruses that cause serious human and animal diseases. Previous studies demonstrated that a determinant within the nsP1/nsP2 cleavage domain of the virulent Sindbis AR86 virus played a key role in regulating adult mouse virulence without adversely affecting viral replication. Additional characterization of this determinant demonstrated that a virus with the attenuating mutation induced more type I IFN production both in vivo and in vitro. Interestingly, this phenotype was not specific to the Sindbis AR86 virus, as a similar mutation in a distantly related alphavirus, Ross River Virus (RRV), also led to enhanced IFN induction. This effect was independent of virus-induced host shutoff, since IRF-3 phosphorylation, which occurs independently of de novo host transcription/translation, was induced more robustly in cells infected with the mutant viruses. Altogether, these results demonstrate that critical determinants within the nsP1/nsP2 cleavage domain play an important role in regulating alphavirus-induced IFN responses.

References

Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·T Ahola, L Kääriäinen
Jun 28, 2003·Journal of Virology·Christopher F BaslerAdolfo García-Sastre
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kui LiStanley M Lemon
Mar 16, 2005·Journal of Virology·Mehul S SutharMark T Heise
Jul 15, 2005·Journal of Virology·Rodion GorchakovIlya Frolov
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yueh-Ming LooMichael Gale
May 30, 2006·Journal of Virology·Natalia GarmashovaIlya Frolov
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Dec 1, 2007·Science·Subba Rao NallagatlaPhilip C Bevilacqua
Apr 18, 2008·Journal of Virology·Rodion GorchakovIlya Frolov
Jul 2, 2008·The Journal of Experimental Medicine·Takeshi Saito, Michael Gale
Sep 13, 2008·Journal of Virology·Thomas E MorrisonMark T Heise

❮ Previous
Next ❯

Citations

Sep 27, 2013·BioMed Research International·Iranaia Assunção-MirandaAndrea T Da Poian
Feb 22, 2012·Journal of Virology·Ilya FrolovElena I Frolova
Sep 6, 2013·Journal of Virology·Kevin J SokoloskiRichard W Hardy
Jul 30, 2015·The Journal of General Virology·Jonathan C RuppRichard W Hardy
Apr 10, 2013·The American Journal of Tropical Medicine and Hygiene·Robert L SeymourScott C Weaver
Jul 14, 2017·Expert Review of Vaccines·Carlo IavaroneJeffrey B Ulmer
Apr 19, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy PepiniCarlo Iavarone
Apr 3, 2015·Journal of Virology·K J SokoloskiR W Hardy
Aug 27, 2021·The Journal of General Virology·Israel Guerrero-ArgueroBrett E Pickett
Aug 29, 2021·Pathogens·Margarita V Rangel, Kenneth A Stapleford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.