Modulation of ultraviolet (UV) transmission by emollients: relevance to narrowband UVB phototherapy and psoralen plus UVA photochemotherapy

The British Journal of Dermatology
S G H OtmanA V Anstey

Abstract

Patients with psoriasis undergoing or about to undergo ultraviolet (UV) phototherapy and photochemotherapy often have thick scale on their plaques which can prevent the penetration of UV radiation. Emollients are used to moisturize the skin and to prevent or reduce some of the milder side-effects ('dryness', itching) sometimes experienced during UV therapy. However, emollients can alter the UV transmission of skin and thus may alter the clinical effects of phototherapy and photochemotherapy. We tested 30 of the topical emollients in the British National Formulary (BNF) using a standard in vitro technique used to test sunscreens. We also surveyed U.K. phototherapy units to establish routine practice for emollient use in phototherapy and photochemotherapy. We used a standard in vitro technique to measure the monochromatic protection factors (MPFs) of 30 non-bath emollients from the BNF. An application rate of 2 mg cm-2 was used. For the assessment of effects during narrowband UVB (TL-01) phototherapy, the mean of the protection factors at 310 and 315 nm was calculated; for psoralen plus UVA photochemotherapy the mean UVA protection factor was used. A questionnaire survey was used to assess routine practice concerning emollient us...Continue Reading

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Citations

Sep 22, 2012·International Journal of Cosmetic Science·A V Rawlings, K J Lombard
Feb 13, 2013·Journal of the American Academy of Dermatology·Manuela L AsztalosJohn Koo
May 4, 2018·Anais Brasileiros De Dermatologia·Sevgi AkarsuAli Tahsin Gunes
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad S HossainEdmund K Waller
Jan 1, 2018·Anais Brasileiros De Dermatologia·Sevgi AkarsuAli Tahsin Gunes

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