Modulation of Vascular Function by AMPK: Assessment of NO Bioavailability and Surrogates of Oxidative Stress

Methods in Molecular Biology
Swenja Kröller-SchönEberhard Schulz

Abstract

The endothelium plays a pivotal role in the development of vascular disease. Decreased bioavailability of nitric oxide, a condition known as "endothelial dysfunction," is considered an early step in this process before atherosclerotic changes of the vessel wall occur. Endothelium-derived nitric oxide (•NO) may be rapidly scavenged by superoxide anions; therefore, the equilibrium between •NO production on one hand and its inactivation by oxidative stress on the other hand is of particular interest. Metabolic enzyme systems such as AMP-activated protein kinase (AMPK) may affect the cellular production of •NO or reactive oxygen species (ROS), while AMPK activity itself can also be modulated by ROS. Therefore, the analysis of •NO as well as ROS levels is essential to understand how metabolism regulating enzymes like AMPK may modulate vascular disease.

Citations

Sep 19, 2018·Oxidative Medicine and Cellular Longevity·Giza Hellen Nonato MirandaRafael Rodrigues Lima
Aug 8, 2021·International Journal of Molecular Sciences·Pamela SenesiIleana Terruzzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
G Muller, H Morawietz
Circulation Journal : Official Journal of the Japanese Circulation Society
Yukihito HigashiYasuki Kihara
The American Journal of Pathology
Parth Patwari, Richard T Lee
© 2022 Meta ULC. All rights reserved