Modulation of very low-density lipoprotein secretion by dietary protein is age-dependent in rats

Annals of Nutrition & Metabolism
M Pfeuffer, C A Barth

Abstract

The Triton WR-1339 technique was used in order to study age-dependent changes of the rate of very low-density lipoprotein (VLDL) lipid secretion in rats consuming either casein or soy protein isolate. There was a significantly higher influx of lipoprotein cholesterol and triglycerides into the plasma compartment (of fasted animals) after a casein than after a soy diet, both in 10-week-old animals (cholesterol: 0.78 +/- 0.06 vs. 0.52 +/- 0.03 mmol X 1(-1) X h-1) and 25-week-old animals (cholesterol: 0.50 +/- 0.07 vs. 0.32 +/- 0.05 mmol X 1(-1) X h-1), but secretion rates diminished with age. The higher secretion rates following casein were paralleled by higher serum cholesterol levels in the fasted younger animals and also, though to a lesser degree, in the fed animals. These data contribute further evidence to our earlier proposal that dietary protein may induce different serum lipid levels by the modulating rate of lipid influx into the plasma compartment.

Citations

Feb 15, 1988·Klinische Wochenschrift·C A Barth, M Pfeuffer
May 22, 1990·Biochimica Et Biophysica Acta·L Sjöblom, A Eklund
Mar 17, 2004·The Journal of Nutritional Biochemistry·John D Radcliffe, Dorice M Czajka-Narins
Oct 7, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Palaniyappan ArivazhaganChinnakkanu Panneerselvam
Nov 15, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B KornmatitsukA Madej
May 1, 1989·The British Journal of Nutrition·Y S ChoiM Sugano
Jul 13, 2000·Nutrition and Cancer·J D Radcliffe, D M Czajka-Narins
Jan 1, 1990·Annals of the New York Academy of Sciences·H Sidransky
Nov 15, 1996·The Journal of Biological Chemistry·K CianfloneA D Sniderman

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.