Modulation/physiology of calcium channel sub-types in neurosecretory terminals.

Cell Calcium
J R LemosGovindan Dayanithi

Abstract

The hypothalamic-neurohypophysial system (HNS) controls diuresis and parturition through the release of arginine-vasopressin (AVP) and oxytocin (OT). These neuropeptides are chiefly synthesized in hypothalamic magnocellular somata in the supraoptic and paraventricular nuclei and are released into the blood stream from terminals in the neurohypophysis. These HNS neurons develop specific electrical activity (bursts) in response to various physiological stimuli. The release of AVP and OT at the level of neurohypophysis is directly linked not only to their different burst patterns, but is also regulated by the activity of a number of voltage-dependent channels present in the HNS nerve terminals and by feedback modulators. We found that there is a different complement of voltage-gated Ca(2+) channels (VGCC) in the two types of HNS terminals: L, N, and Q in vasopressinergic terminals vs. L, N, and R in oxytocinergic terminals. These channels, however, do not have sufficiently distinct properties to explain the differences in release efficacy of the specific burst patterns. However, feedback by both opioids and ATP specifically modulate different types of VGCC and hence the amount of AVP and/or OT being released. Opioid receptors have...Continue Reading

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Citations

Jan 9, 2013·Stem Cells and Development·Oksana ForostyakGovindan Dayanithi
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Sep 17, 2014·Trends in Pharmacological Sciences·Beáta Sperlágh, Peter Illes
Feb 26, 2016·Cell Calcium·Oksana ForostyakGovindan Dayanithi
Feb 21, 2013·Alcoholism, Clinical and Experimental Research·Andrzej Z PietrzykowskiSteven N Treistman
Mar 6, 2012·Cell Calcium·Govindan DayanithiEmil C Toescu
May 12, 2015·Autonomic Neuroscience : Basic & Clinical·Ivana BjelobabaStanko S Stojilkovic
Mar 6, 2012·Cell Calcium·Emil C Toescu, Govindan Dayanithi
Oct 9, 2012·Neuron·Anthony N van den Pol
Mar 8, 2018·Journal of Neuroendocrinology·José R LemosSonia Ortiz-Miranda
Dec 7, 2018·Journal of Neuroendocrinology·William E ArmstrongCelia D Sladek
May 15, 2020·Journal of Neuroendocrinology·Colin H BrownJavier E Stern
Apr 1, 2020·Journal of Neuroendocrinology·Cristina Velázquez-MarreroJosé R Lemos
Dec 18, 2020·Frontiers in Neurology·Paola PerinCinzia Boselli
Dec 24, 2021·Journal of Neuroendocrinology·Stephanie ConstantinRichard Piet

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