Abstract
Berberine, an isoquinoline alkaloid isolated from medicinal plants such as Berberis aristata, Coptis chinesis, Coptis japonica, Coscinium fenestatun, and Hydrastis Canadensis, is widely used in Asian countries for the treatment of diabetes, hypertension, and hypercholesterolemia. Interaction between berberine and the cytochrome P450 enzymes (CYPs) has been extensively reported, but there are only a few reports of this interaction in the diabetic state. In this study, the effect of berberine on the mRNA of the CYPs in primary mouse hepatocytes and in streptozotocin (STZ)-induced diabetic mice was investigated. In primary mouse hepatocytes, berberine suppressed the induction of Cyp1a1, Cyp1a2, Cyp2e1, Cyp3a11, Cyp4a10, and Cyp4a14 mRNA expression by their prototypical inducers in a concentration-dependent fashion. However, berberine treatment alone increased the expression of Cyp2b9 and Cyp2b10 mRNA. In vivo, berberine showed the same hypoglycemic activity as metformin, an established hypoglycemic drug. The hepatic mRNA levels of Cyp1a1, Cyp2b9, Cyp2b10, Cyp3a11, Cyp4a10, and Cyp4a14 were increased in STZ-induced diabetic mice. Interestingly, berberine itself suppressed the expression of Cyp2e1, an adverse hepatic event-associate...Continue Reading
References
Sep 1, 1989·DNA·S KimuraF J Gonzalez
Aug 17, 1993·Biochemical Pharmacology·N ShimojoK Okuda
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M D WeltmanC Liddle
Sep 4, 1998·Diabetes Care·H KingW H Herman
Jan 9, 1999·Toxicology·B G LakeD C Evans
Aug 27, 1999·Archives of Biochemistry and Biophysics·K JarukamjornN Nemoto
Jun 27, 2000·Diabetes·B SoriaF Martín
Nov 25, 2000·Toxicology·C DelescluseR Rahmani
Jul 24, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T SakumaN Nemoto
Jan 22, 2003·British Journal of Clinical Pharmacology·Zaiqi WangJ C Gorski
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kartik ShankarHarihara M Mehendale
Oct 23, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Parnali Chatterjee, Michael R Franklin
Apr 28, 2004·Diabetes Care·Sarah WildHilary King
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Koji HayashiMikio Ito
Jun 9, 2006·Journal of Ethnopharmacology·Li-Qin TangSheng Liu
Apr 10, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuan ZhaoGuo-Liang Zhang
Dec 7, 2007·Chemical Research in Toxicology·F Peter Guengerich
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Yifei ZhangGuang Ning
Apr 17, 2009·Phytotherapy Research : PTR·W QiuJ X Jin
Sep 10, 2009·Chemico-biological Interactions·Waranya ChatuphonprasertNobuo Nemoto
Sep 14, 2010·Journal of Ethnopharmacology·Cheryl L K KoideJun Panee
Jun 1, 2011·Fitoterapia·Waranya ChatuphonprasertKanokwan Jarukamjorn
Aug 2, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Chang ZhouJun-Fang Zhou
Sep 17, 2011·Journal of Ethnopharmacology·Ying GuoCurtis D Klaassen
Citations
Nov 19, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Sakshi GuptaAmteshwar Singh Jaggi
Dec 3, 2014·Journal of Ethnopharmacology·Han-Ming CuiXiao-Lin Tong
May 29, 2012·Journal of Ethnopharmacology·K Hoa NguyenB L Grégoire Nyomba
Nov 6, 2013·Pharmaceutical Biology·Waranya ChatuphonprasertKanokwan Jarukamjorn
May 16, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Duo ZhiBao-Xin Li
Feb 18, 2014·The American Journal of Cardiology·Andrew Brenyo, Mehmet K Aktas
Nov 19, 2015·Biomedical Chromatography : BMC·Guofei LiLimei Zhao
Jan 29, 2014·The American Journal of Chinese Medicine·Chenrui LiQibing Mei
Mar 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan ZhangYoufei Guan
Sep 18, 2018·Drug Metabolism Reviews·Feng ChenJing Xu
Mar 16, 2018·Chinese Medicine·Fan-Cheng MengQing-Wen Zhang
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Jichun Yang, Youfei Guan
Jan 17, 2019·Journal of Food and Drug Analysis·Kuo-Chen Wu, Chun-Jung Lin
May 7, 2020·Food & Function·Noelia Morales-PrietoNieves Abril
Sep 26, 2019·Scientific Reports·Kathrine Sivertsen ÅsrudMarit Bakke
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuexiao CaoXiaoliang Ren
May 13, 2017·BioMed Research International·Jie LiYanwei Xing
Aug 9, 2020·Drug and Chemical Toxicology·Azra BozcaarmutluDidem Ekşioğlu
Jun 27, 2020·Current Drug Metabolism·Bao SunRuixia Yang
Apr 28, 2021·Drug Metabolism Reviews·Junmei ChenQi Wang
Sep 13, 2017·Life Sciences·Bo JiangGuiliang Zhang