May 17, 2014

Modulators affecting the immune dialogue between human immune and colon cancer cells

World Journal of Gastrointestinal Oncology
Meir Djaldetti, Hanna Bessler

Abstract

The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells (PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosis factor-α, Interleukin (IL)-6, IL-10, IL-12, IL-...Continue Reading

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Mentioned in this Paper

Interleukins
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Tumor Necrosis Factor-alpha
Cross-talk
Angiogenic Process
Peripheral Blood Mononuclear Cells (Lab Test)
Recombinant Interleukin-10
Migration Inhibitory Factor Assay
Recombinant Interleukin-5

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