PMID: 20645920Jul 22, 2010Paper

Modulators of multidrug resistance associated proteins in the management of anticancer and antimicrobial drug resistance and the treatment of inflammatory diseases

Current Topics in Medicinal Chemistry
An-Kui YangShu-Feng Zhou

Abstract

Human multidrug resistance protein (MRP/ABCC) family contains 9 members (MRP1-9) which transport a structurally diverse array of anticancer and antimicrobial drugs and several important endogenous substances including prostaglandins (PGs) and leukotrienes (LTs) with different substrate specificity. MRP1-5 can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, and alkylating agents. MRP1-3 are often associated with tumor resistance which is often caused by an increased efflux and decreased intracellular accumulation of natural product anticancer drugs and other anticancer agents. Both PGE(1) and PGE(2) are known high-affinity substrates of MRP4, but not MRP1, MRP2, MRP3 and MRP5. LTC(4) is a substrate of MRP1, MRP2, MRP3, and MRP6-8. MRP2 is also able to transport LTD(4) and LTE(4). Experimental studies in Abcc1-difficient mice have demonstrated a role of MRP1 in inflammation process in vivo. Abcc3-difficient mice have normal bile salt transport, however they have decreased blood bilirubin glucuronide levels. Abcc6-difficient mice show remarkable mineraliztion of the connective tissues, including skin,...Continue Reading

Citations

Nov 1, 2011·International Journal for Parasitology·Paula C PohlAoi Masuda
Feb 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakub Kryczka, Joanna Boncela
May 29, 2012·ChemMedChem·Richard J FairYitzhak Tor
Feb 11, 2020·American Journal of Physiology. Renal Physiology·Eduardo C AlexandreNaoki Yoshimura
Mar 13, 2020·Journal of Ovarian Research·Haixia LiLimin Feng
Jan 30, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jing-Quan WangZhe-Sheng Chen
May 3, 2011·Bioorganic & Medicinal Chemistry·Kalam SirishaVanga Malla Reddy
Nov 27, 2021·Integrative Cancer Therapies·Luchang CaoJie Li

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