PMID: 11324541Apr 28, 2001Paper

Modulatory action of alpha 2-adrenoceptor on calcitonin gene-related peptide release from rat mesenteric arterial bed

Sheng li xue bao : [Acta physiologica Sinica]
W SunX Wang

Abstract

The release of calcitonin gene-related peptide (CGRP) from peripheral terminals of sensory nerves was modulated via multiple mechanisms. In the present study, pharmacological agents were used to investigate the modulatory action of alpha 2-adrenoceptor on endotoxin-induced CGRP release from isolated perfused rat mesenteric arterial bed. The results showed that UK14304 (3 x 10(-6) mol/L), a potent alpha 2-adrenoceptor agonist, significantly inhibited both basal and endotoxin-induced CGRP release by 22%-42%, while specific antagonist of alpha 2-adrenoceptor yohimbine (10(-5) mol/L) blocked the effect of UK14304 completely. The data suggest that presynaptic alpha 2-adrenoceptor has an inhibitory effect on basal and endotoxin-induced CGRP release. Dysfunction of alpha 2-adrenoceptor in the late stage of endotoxic shock may be involved in the excess release of CGRP from the peripheral nerves.

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