Modulatory actions of neurotransmitters

Annual Review of Neuroscience
I Kupfermann


A relatively shorttime ago the individual neuron was viewed as functioning by means of the simple summation of brief inhibitory or excitatory events. The complexity of the nervous system was the outcome largely of the connections between neurons. Recent studies have uncovered a new set of phenomena that indicate that relatively complex information processing may occur at the level of the individual neuron. For example, rather than producing additive effects, synaptic inputs can produce multiplicative effects that serve to alter the gain of the system. In addition, synaptic inputs may be able to alter specific classes of other inputs selectively. One could envision that each class of synaptic input to a cell could be selectively depressed or enhanced by a corresponding modulatory input. Since the modulatory actions can be transmitted intracellularly via second messengers, an extensive array of presynaptic connections may be unnecessary. It remains to be determined which of the modulatory phenomena currently reviewed are functionally important and which are only pharmacological or experimental curiosities. Are there any common attributes of the various synaptic phenomena that have been termed modulatory? The most common features ...Continue Reading


Oct 1, 1986·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·P D Brodfuehrer, W O Friesen
Oct 1, 1986·Pflügers Archiv : European journal of physiology·C G CaratschF Eusebi
Mar 1, 1984·Neurochemical Research·E Florey
Jun 1, 1982·Journal of Autism and Developmental Disorders·R D CiaranelloT F Anders
Jan 1, 1992·Molecular Neurobiology·J K Wamsley
Oct 14, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Wolfgang Stein
Jan 1, 1987·Pharmacology & Therapeutics·K Brück, E Zeisberger
Jan 1, 1989·Pharmacology & Therapeutics·G A Cottrell, G S Bewick
Jan 1, 1983·Neurochemistry International·M I RudolphG Bustos
Oct 1, 1993·Neurochemistry International·P Bach-y-Rita
Sep 16, 1985·Neuroscience Letters·T Crow, M S Bridge
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·K Kaila
Feb 1, 1984·Neuroscience·R S GoldsteinJ H Schwartz
Dec 1, 1986·Brain Research Bulletin·L S Benardo, R E Foster
Apr 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Sivasubramanian
Jan 9, 1998·Progress in Neurobiology·L DescarriesM Steriade
Apr 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J R StrawnRobin L Cooper
Jan 13, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B GriffisRobin L Cooper
Jan 1, 1988·Visual Neuroscience·J R Wilson, A E Hendrickson
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R LlinásS M Simon
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B L TempelW G Quinn
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F WorleyS H Snyder
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Crow, J Forrester
Apr 1, 1980·Epilepsia·M S Myslobodsky, E S Valenstein
Jan 1, 1985·Epilepsia·D A Prince
May 4, 2012·Journal of Neurophysiology·Andrew M DacksAlan J Nighorn
Mar 23, 2012·Biology of Sex Differences·William R Mowrey, Douglas S Portman
Jan 1, 2009·Reviews in the Neurosciences·Jian JingKlaudiusz R Weiss
Dec 1, 1983·The International Journal of Neuroscience·B RockstrohH L Fehm
Oct 30, 2009·Journal of Neurogenetics·Andrew M DacksJing W Wang
Apr 8, 2011·Expert Review of Neurotherapeutics·Gary RemingtonGeorge Foussias
May 12, 2012·Progress in Neurobiology·Abraham J Susswein, Hillel J Chiel
Sep 13, 2008·Trends in Neurosciences·Yukiori Goto, Anthony A Grace
May 15, 2007·Brain Research Reviews·François Clarac, Edouard Pearlstein
Jun 21, 2011·Developmental Neurobiology·Jing W Wang
Nov 16, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Sarah A Stern, Cristina M Alberini
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Maurice-Pierre Pagé, Robin L Cooper
Aug 18, 1987·Brain Research·G A MarksH P Roffwarg
Oct 14, 1982·Brain Research·L S Benardo, D A Prince
Oct 9, 2012·Neuron·Ron Stoop
Mar 14, 2007·International Review of Neurobiology·Yukiori Goto, Anthony A Grace
May 5, 1983·Nature·M S Livingstone, B L Tempel
Jan 1, 1991·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R S Goldstein, J M Camhi
Mar 1, 1987·Neuroscience and Behavioral Physiology·Z G Mamedov
Jun 2, 2006·Journal of Neurophysiology·Geidy E Serrano, Mark W Miller
Mar 7, 2008·Journal of Neurophysiology·Andrew M DacksJ G Hildebrand
Nov 21, 2014·Journal of Neurophysiology·Miranda J CullinsHillel J Chiel
Sep 1, 1984·Behavior Genetics·T Tully
Feb 19, 2016·Journal of Neurophysiology·Bridget N RalstonJohn T Birmingham
Jul 21, 2017·The Journal of Experimental Biology·Michael P Nusbaum
Nov 13, 2015·The Journal of Comparative Neurology·Kristyn M LizbinskiAndrew M Dacks
Jan 30, 2018·Frontiers in Cellular Neuroscience·Kristyn M Lizbinski, Andrew M Dacks
Sep 1, 2020·PLoS Genetics·Maureen M SampsonDavid E Krantz

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