Modulatory effect of erythrocytes on the platelet reactivity to collagen in IDDM patients

Diabetes
J VallesR Carmena

Abstract

Platelets participate in the atherothrombotic complications of diabetes. Recent data demonstrate that platelet reactivity can be modulated via cell-cell interactions with erythrocytes and neutrophils. In this study, platelet reactivity was evaluated in 30 IDDM patients. We used an analytical procedure that permits an independent evaluation of platelet activation (granule release, eicosanoid formation) and platelet recruitment (pro-aggregatory activity of cell-free releasates) after platelet stimulation with collagen in the presence or absence of other blood cells. The interaction between platelets and erythrocytes (hematocrit 40%) resulted in a marked enhancement of platelet activation (5HT, betaTG, TXA2 release) and recruitment in both patients and control subjects. The erythrocyte enhancement of platelet TXA2 synthesis and recruitment was significantly higher in the patients, while no differences were detected in platelet granule release. The elevated platelet recruitment in the IDDM patients was found to be due to 1) increased susceptibility of diabetic platelets to the prothrombotic effect of erythrocytes and 2) the greater response of diabetic platelets to their own cell-free releasate. Patients with poor metabolic control...Continue Reading

Citations

Jun 13, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-François HardyUNKNOWN Members of the Groupe d'Intérêt en Hémostase Périopératoire
Aug 11, 2000·Diabetes Research and Clinical Practice·A B Sobol, C Watala
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-François HardyUNKNOWN Groupe d'intérêt en Hémostase Périopératoire
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Dominick J Angiolillo
Jun 13, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Dominick J Angiolillo, Siva Suryadevara
Jul 29, 2008·Pharmacotherapy·Anita AireeShannon W Finks
Aug 6, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jean-François Hardy
Dec 30, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F BursiM G Modena
Mar 20, 2008·Cerebrovascular Diseases·Cathy M HelgasonLarry D Brace
Aug 20, 2020·Biophysical Journal·Yixiang DengGeorge Em Karniadakis

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