Modulatory effect of Gymnema montanum leaf extract on brain antioxidant status and lipid peroxidation in diabetic rats

Journal of Medicinal Food
Kunga Mohan RamkumarVengatesh Narmatha Bai

Abstract

The effects of leaf extract from Gymnema montanum, an endangered and endemic plant, were examined on brain lipid peroxidation in experimental diabetic rats. Ethanolic extract of G. montanum leaves was administered orally (50, 100, and 200 mg/kg of body weight) for 3 weeks, and changes in blood glucose, plasma insulin, and lipid peroxidation markers such as thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and levels of antioxidants, namely, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and glutathione-S-transferase, were examined in the brain of alloxan-induced diabetic rats. Glibenclamide was used as a standard reference drug. A significant increase in the activities of antioxidants was observed in brain on treatment with G. montanum leaf extract and glibenclamide for 3 weeks. Both the treated groups showed significant decreases in formation of TBARS and hydroperoxides in brain, suggesting a role in protective action against lipid peroxidation-mediated membrane damage. Our findings indicate that G. montanum leaf extract possesses antiperoxidative and antioxidant effects in addition to its antidiabetic activity. This report helps to create awareness on the need for conservation of m...Continue Reading

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Citations

Aug 15, 2018·Current Diabetes Reports·Zeinab Nazarian-SamaniMahmoud Rafieian-Kopaei
Dec 11, 2008·Basic & Clinical Pharmacology & Toxicology·Kunga Mohan RamkumarPalanisamy Rajaguru
Sep 29, 2005·Journal of Basic and Clinical Physiology and Pharmacology·Kunga Mohan RamkumarRajendran Ananthan
Dec 29, 2016·Reviews in the Neurosciences·Sita Sharan Patel, Malairaman Udayabanu

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