Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction

European Journal of Pharmacology
Sai Wang SetoSai Ming Ngai


An increased level of cytokine interleukin-1 (IL-1) has been detected around the site of stroke. However, the effect of IL-1beta on the basilar artery has received little attention. We evaluated the effects of IL-1beta on the contractile response of rat isolated basilar artery by measuring isometric tension change. IL-1beta (10 ng/ml) and phenylephrine (0.1 nM) markedly enhanced U46619 (30 and 100 nM)-induced basilar artery contraction. The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.


Jan 1, 1992·The Journal of Physiology·M A MurrayD D Heistad
Nov 1, 1991·Brain Research Bulletin·S SatohA Saito
Jan 1, 1989·The Journal of Clinical Investigation·D BeasleyN G Levinsky
Jun 1, 1994·Journal of Cardiovascular Pharmacology·C M BoulangerP M Vanhoutte
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·Y YamasakiK Kogure
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·T KitazonoM Fujishima
Jul 27, 1999·Journal of Biomedical Science·Y M MurthaJ A Orr
Mar 1, 2000·Journal of Neuroimmunology·O TouzaniN Rothwell
Mar 16, 2000·Neuroscience Letters·J J LegosF C Barone
Feb 14, 2002·Mechanisms of Ageing and Development·Dahuk El-Assouad, Seyed Khosrow Tayebati
Oct 9, 2002·Journal of Internal Medicine·G J Blake, P M Ridker
Mar 5, 2003·Pharmacological Reviews·Jan H von der ThüsenErik A L Biessen
Dec 26, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Katsunari TasakiIchiro Wakabayashi
May 18, 2004·Journal of Neuroimmunology·Beáta SperlághE Sylvester Vizi
May 25, 2004·Stroke; a Journal of Cerebral Circulation·Suk-Ying TsangYu Huang
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Elisabet Vila, Mercedes Salaices


Apr 21, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y SunL-L Wen
Jun 11, 2015·International Journal of Endocrinology·S W SetoD Chang
Feb 5, 2010·British Journal of Pharmacology·Sai Wang Seto, J R Docherty
Jan 10, 2017·International Journal of Molecular Sciences·Sai Wang SetoJianxun Liu

Related Concepts

Zinc protoporphyrin IX
NSC 667676
Adrenergic alpha-Antagonists
Structure of Basilar Artery
Dose-Response Relationship, Drug
Enzyme Inhibitors

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.