Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction

European Journal of Pharmacology
Sai Wang SetoSai Ming Ngai

Abstract

An increased level of cytokine interleukin-1 (IL-1) has been detected around the site of stroke. However, the effect of IL-1beta on the basilar artery has received little attention. We evaluated the effects of IL-1beta on the contractile response of rat isolated basilar artery by measuring isometric tension change. IL-1beta (10 ng/ml) and phenylephrine (0.1 nM) markedly enhanced U46619 (30 and 100 nM)-induced basilar artery contraction. The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.

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Citations

Apr 21, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y SunL-L Wen
Jun 11, 2015·International Journal of Endocrinology·S W SetoD Chang
Feb 5, 2010·British Journal of Pharmacology·Sai Wang Seto, J R Docherty
Jan 10, 2017·International Journal of Molecular Sciences·Sai Wang SetoJianxun Liu

Related Concepts

Zinc protoporphyrin IX
NSC 667676
4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Adrenergic alpha-Antagonists
Metazoa
Structure of Basilar Artery
Dose-Response Relationship, Drug
Enzyme Inhibitors
Bioflavonoids

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