PMID: 11328382May 1, 2001Paper

Modulatory effect of prostaglandins on human monocyte activation for killing of high- and low-virulence strains of Paracoccidioides brasiliensis

Immunology
A M SoaresA R Dos Anjos

Abstract

The effect of indomethacin (Indo), a cyclo-oxygenase inhibitor, on the monocyte-mediated killing of a low- (Pb265) and a high- (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non-activated or interferon-gamma (IFN-gamma) -activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN-gamma, tumour necrosis factor-alpha (TNF-alpha) was very effective at stimulating the fungicidal activity of monocytes. While the low-virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN-gamma demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo-oxygenase pathway, in the regulation of monocyte-mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF-alpha generation during the fungus-monocyte interaction is more important in the killing of Pb265 than Pb18.

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Citations

Feb 6, 2002·Trends in Microbiology·M Ines Borges-WalmsleyAdrian R Walmsley
Mar 26, 2003·Microbes and Infection·Sueli A CalviAngela M V C Soares
May 10, 2003·Microbes and Infection·Maria T S PeraçoliAngela M V C Soares
Nov 6, 2009·Medical Mycology·Camila Vicente BonfimMaria Heloisa Souza Lima Blotta
Jan 23, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carolina H Pohl, Johan L F Kock
Apr 21, 2006·Microbiology and Immunology·Luciane Alarcão Dias-MelicioAngela Maria Victoriano de Campos Soares
Apr 21, 2007·Microbiology and Immunology·Cilmery Suemi KurokawaMaria Terezinha S Peraçoli
May 26, 2012·Yeast·Guilherme Augusto BiondoAngela Maria Victoriano de Campos Soares
Apr 26, 2007·FEMS Immunology and Medical Microbiology·Luciane Alarcão Dias-MelicioAngela Maria Victoriano Campos Soares
Apr 19, 2012·Memórias do Instituto Oswaldo Cruz·Sheisa Cyléia SargiJeane Eliete Laguila Visentainer
Dec 2, 2010·Memórias do Instituto Oswaldo Cruz·Camila Ferreira BannwartMaria Terezinha S Peraçoli
Nov 23, 2005·Revista Do Instituto De Medicina Tropical De São Paulo·Cilmery S KurokawaMaria T S Peraçoli
Nov 8, 2017·Mycoses·Alexandre Giannecchini RomagnoloLuciane Alarcão Dias-Melicio
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May 23, 2008·Mycopathologia·Magda Paula Pereira do NascimentoMaria Terezinha Serrão Peraçoli
Apr 7, 2010·Mycopathologia·Guilherme Augusto BiondoAngela Maria Victoriano Campos Soares
Sep 9, 2008·Mycopathologia·Vera Lúcia Garcia CalichAdriana Pina
Mar 28, 2021·Microbial Pathogenesis·Grazzielle Guimarães de MatosFátima Ribeiro-Dias

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