Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors

Pharmacotherapy
Issam ZinehNasser Chegini

Abstract

To investigate the immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) by determining whether atorvastatin alters the production of specific endothelium-derived immunoactive proteins and whether its treatment effects depend on its concentration and/or inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. In vitro study using a multiplexing method for protein measurement. University laboratory. Human umbilical vein endothelial cells were cultured to approximately 80% confluence and treated with atorvastatin 1-50 microM alone or with mevalonate for 24 hours. Untreated cells served as controls. Culture-conditioned media were removed and multiplex assayed for protein content of epithelial neutrophil-activating peptide-78, interleukin-8, monocyte chemotactic protein-1, interleukin-6, interleukin-10, fibroblast growth factor, and granulocyte colony stimulating factor. Atorvastatin significantly reduced the production of epithelial neutrophil-activating peptide-78, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 (p<0.001 to p<0.05) in a concentration-dependent manner without affecting basal production of interleukin-10, fibroblast growth factor, and granulocyte col...Continue Reading

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Citations

Jan 26, 2012·Cardiovascular Drugs and Therapy·Elvin Tyrone PriceIssam Zineh
May 6, 2009·Seminars in Immunopathology·Fabrizio Montecucco, François Mach
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