Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

Indian Journal of Clinical Biochemistry : IJCB
Govindasami ChandirasegaranKavisa Ghosh

Abstract

The goal of the present study was to evaluate the effect of Berberine chloride (BC) on lipid profile, oxidant status and insulin signaling molecules in Streptozotocin (STZ) induced diabetic rat model. Diabetes was induced in rats by a single dose of intraperitoneal administration of STZ (40 mg/kg b.w). Diabetic rats were treated with BC (50 mg/kg b.w) and glibenclamide (6 mg/kg b.w) for 45 days. BC treated diabetic rats showed significant (p <0.05) decrease in the levels of TC, TG, phospholipids, LDL, VLDL and lipid peroxidation markers such as LOOH and TBARS. An increase in enzymatic antioxidant (SOD, CAT and GPx), non-enzymatic antioxidant (GSH, vitamin C and E) and insulin signaling molecules expression, like Insulin receptor substrate-1 (IRS-1), Protein kinase B (PKB or Akt) and glucose transporter-4 (GLUT-4) were found to be significantly raised in BC treated STZ induced diabetic rats. Thus, the results of the current study demonstrated that BC significantly reversed the abnormal levels of lipids, oxidant status and insulin signaling molecules in the diabetic rat model, which may be contributed to its anti-diabetic and antioxidant activities.

References

Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Oct 18, 1995·Molecular and Cellular Biochemistry·R KakkarK Prasad
May 1, 1997·Endocrinology·J F TantiY Le Marchand-Brustel
Jan 28, 1999·The Journal of Biological Chemistry·M J CharronA L Olson
Apr 2, 1999·European Journal of Biochemistry·S X Chen, P Schopfer
Mar 10, 2001·Recent Progress in Hormone Research·R T Watson, J E Pessin
May 7, 2002·The Journal of the Royal Society for the Promotion of Health·E C Opara
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jun 1, 1952·Archives of Biochemistry and Biophysics·B CHANCEF J W ROUGHTON
Feb 27, 2004·Diabetes, Obesity & Metabolism·Andrew J Krentz
Nov 25, 2005·Diabetes·Bartholomew A PedersonPeter J Roach
Jan 18, 2006·The Journal of Nutritional Biochemistry·Christopher P F MarinangeliPeter J H Jones
Jan 2, 2007·Journal of Ethnopharmacology·P N PushparajC H Tan
Dec 11, 2007·Journal of Ethnopharmacology·T S Fröde, Y S Medeiros
Mar 18, 2008·Journal of Applied Toxicology : JAT·V R PunithavathiP Stanely Mainzen Prince
Jul 19, 2008·European Journal of Pharmacology·Govindasamy ChandramohanKodukkur Viswanathan Pugalendi
Jun 11, 2011·European Journal of Pharmacology·Rangachari BalamuruganSavarimuthu Ignacimuthu
Aug 19, 2014·Bioorganic & Medicinal Chemistry Letters·Gabriel Navarrete-VázquezJulio César Almanza-Pérez
Aug 27, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Govindasami ChandirasegaranSubramaniam Sethupathy

❮ Previous
Next ❯

Citations

Mar 7, 2020·Frontiers in Pharmacology·Tarun BelwalJavier Echeverría
Aug 10, 2021·Tissue & Cell·Ghadha Ibrahim Fouad, Kawkab A Ahmed

❮ Previous
Next ❯

Software Mentioned

Total Lab
SPSS Statistics

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Govindasami ChandirasegaranKavisa Ghosh
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Govindasami ChandirasegaranS Sethupathy
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
G KumarA G Murugesan
Redox Report : Communications in Free Radical Research
Khalid S Al-NumairMohammed A Alsaif
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Priyanka BagriShahnaz Sultana
© 2021 Meta ULC. All rights reserved