PMID: 7536059Dec 1, 1994Paper

Modulatory effects of calcitonin gene-related peptide and substance P on human cholinergic sweat secretion

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
K KumazawaT Ogawa

Abstract

Immunoreactivity to various peptides has been demonstrated in nerve terminals around the sweat glands, suggesting a regulatory function for these peptides on sweating. The present study evaluated the calcitonin-gene related peptide and substance P related regulation of sweating in man. Both calcitonin-gene related peptide and substance P, when administered alone, failed to cause sweat secretion, whereas sweating induced by methacholine chloride alone was four times greater when administered with calcitonin-gene related peptide and suppressed by 70% when administered with substance P. The degree of calcitonin-gene related peptide dependent augmentation and substance P dependent suppression of the methacholine chloride induced sweating was dependent on the concentration of calcitonin-gene related peptide and substance P. These findings suggest that calcitonin-gene related peptide enhances cholinergic sweating and substance P inhibits it.

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Citations

Apr 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·K KumazawaT Ogawa
May 31, 2003·Mediators of Inflammation·Freek J ZijlstraJan Klein
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junsuke KawaiToshiro Fujita
Dec 29, 2009·Frontiers in Bioscience (Scholar Edition)·Manabu Shibasaki, Craig G Crandall
Aug 26, 2006·The Journal of Physiology·Tanja SchlerethFrank Birklein
Jun 16, 2012·Neuropeptides·Jorge J VilchesXavier Navarro
Sep 17, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Anupama PoudelSatoshi Kuwabara
Jul 1, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·James PearsonCraig G Crandall
Dec 26, 2018·European Journal of Pain : EJP·Charlotte GuhlSilke Hirsch
Apr 15, 2006·Journal of Applied Physiology·Manabu ShibasakiCraig G Crandall
Oct 12, 2018·Endocrine·Maria Alice OliveiraValéria Ernestânia Chaves

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