Modulatory effects of different exercise modalities on the functional connectivity of the periaqueductal grey and ventral tegmental area in patients with knee osteoarthritis: a randomised multimodal magnetic resonance imaging study

British Journal of Anaesthesia
Jiao LiuJian Kong

Abstract

Knee osteoarthritis is a prevalent disorder with unsatisfactory treatment options. Both physical and mindful exercises may be able to relieve its pain symptoms. We compared the modulatory effects of different exercise modalities on the periaqueductal grey (PAG) and ventral tegmental area (VTA), which play important roles in descending opioidergic pathways and reward/motivation systems in patients with knee osteoarthritis. We recruited and randomised 140 patients into Tai Chi, Baduanjin, stationary cycling, and health education control groups for 12 weeks. Knee injury and Osteoarthritis Outcome Score (KOOS), functional and structural MRI, and blood biomarkers were measured at the beginning and end of the experiment. We used the PAG and VTA as seeds in resting-state functional connectivity (rsFC) analysis. Compared with the control group: (i) all exercises significantly increased KOOS pain sub-scores (pain reduction) and serum programmed death 1 (PD-1) concentrations; (ii) all exercises decreased right PAG rsFC with the medial orbital prefrontal cortex, and the decreased rsFC was associated with improvements in knee pain; and (iii) grey matter volume in the medial orbital prefrontal cortex was significantly increased in all exerc...Continue Reading

Citations

Nov 28, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaorong ChenAlbert Yeung
Sep 26, 2019·Frontiers in Aging Neuroscience·Jiao LiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 9, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jianqi FangXiaowen Lian
Mar 6, 2021·Musculoskeletal Care·Filipe RaposoAna Lúcia Cruz
May 8, 2021·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jinhai LinDanping Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.