Modulatory effects of endothelin-1 on central cardiovascular control in rats

The Japanese Journal of Physiology
T KuwakiM Kumada

Abstract

In urethane-anesthetized and immobilized rats, modulatory effects of endothelin-1 (ET-1) on central cardiovascular control were examined. An injection of 0.1 pmol of ET-1 into the cisterna magna caused immediate increases in arterial pressure (AP), renal sympathetic nerve activity (RSNA), and heart rate (HR) that lasted for 5-45 min. At doses of 1 and 10 pmol, intracisternal ET-1 elicited initial increases (phase I) followed by decreases in these variables below the pre-injection level (phase II). At the dose of 1 or 10 pmol, the arterial baroreceptor reflex was suppressed during the latter part of phase I and during phase II. The three variables subsequently returned to, or often exceeded, pre-injection levels in 30 to 60 min and reflex activity recovered (phase III). However, AP often remained below control throughout the 2-h observation period. Essentially identical responses to intracisternal ET-1 were observed in unanesthetized precollicular decerebrated or urethane-anesthetized rats. Application of a piece of filter paper soaked with 1 pmol of ET-1 to the ventral surface of the medulla (VSM) caused the pattern of changes similar to the following intracisternal injection. A microinjection of 4 pmol of ET-1 into the nucleus...Continue Reading

Citations

Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·T KuwakiY Fukuda
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuko TsuchiyamaIchiro Nishio
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y KuriharaT Kuwaki

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