Modulatory effects of Saussurea lappa root aqueous extract against ethephon-induced kidney toxicity in male rats

Environmental Toxicology
Ehab ToussonAssem Abdallah

Abstract

Ethephon (2-chloroethyl phosphonic acid) is a plant growth promoter used to control the plant growth process by liberating ethylene and stimulating the production of endogenous ethylene. Medicinal plants are sources of novel drug discovery targets. Costus (Saussurea lappa) has been used as traditional Chinese medicine. The current study was conducted to examine the possible modifying effects of costus (S. lappa) root aqueous extract against kidney toxicity induced by ethephon in male rats. A total of 50 adult male rats were divided into five groups (first, control; second, costus; third, ethephon; fourth, posttreated ethephon with costus; fifth, ethephon self-healing). There is a significant increase in the serum levels of urea, creatinine, potassium ions, chloride ions, kidney injury, DNA damage, and proliferating cell nuclear antigen expressions in treated rats with ethephon when compared to the control group. In contrast, the treated rats with ethephon revealed a significant decrease in the levels of sodium ions and an insignificant decrease in the calcium ions. Saussurea lappa extract modified these alterations when compared to the control group. As a result, costus root extract significantly reduced rat kidney toxicity aft...Continue Reading

References

Feb 26, 2008·Toxicology·Michael A FergusonJoseph V Bonventre
Aug 30, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Qi ZhangJianhua Liu
Jun 1, 2010·Journal of Food Science and Technology·B V C MahajanB S Chahil
Jul 9, 2013·Journal of Advanced Pharmaceutical Technology & Research·T S Mohamed SaleemM N Vishnu
Oct 2, 2013·Toxicology and Industrial Health·Ehab ToussonAmani Akel
Oct 8, 2013·Toxicology and Industrial Health·Ehab Tousson
Jan 29, 2014·Preventive Nutrition and Food Science·Kyung-Mi ChangGun-Hee Kim
Jul 11, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shalini SagguHasibur Rehman
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Kulsoom ZaharaSunbal Khalil Chaudhari
Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J ChienS-C Tang
Jul 29, 2016·Environmental Science and Pollution Research International·Ehab ToussonAmani Gad
Mar 17, 2015·JBJS Reviews·William M Ricci
Dec 18, 2016·Environmental Toxicology and Pharmacology·Siqi WangXuetao Wei
Dec 1, 2017·BMC Bioinformatics·Curtis T RuedenKevin W Eliceiri
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ehab ToussonAlaa A Ahmed
Oct 14, 2018·Environmental Toxicology·Mabrouk Attia Abd EldaimWalaa Mohamed Awd
Feb 14, 2019·Oxidative Medicine and Cellular Longevity·Maha A AldubayanEhab Tousson
May 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mabrouk Attia Abd EldaimHebatalla Nashaat Elsharkawy

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