Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei

Journal of Neurophysiology
Fumihito SaitowHidenori Suzuki

Abstract

Cerebellar outputs from the deep cerebellar nuclei (DCN) are critical for generating and controlling movement. DCN neuronal activity is primarily controlled by GABAergic inhibitory transmission by Purkinje cells in the cerebellar cortex and is also modulated by nerve inputs originating from other brain regions within and outside the cerebellum. In this study, we examined the modulatory effects of 5-HT on GABAergic synapses in the DCN. 5-HT decreased the amplitude of stimulation-evoked inhibitory postsynaptic currents (eIPSCs) in DCN neurons, and this effect was abolished by a 5-HT(1B) antagonist, SB 224289. The decrease in IPSC amplitude was associated with an increased paired-pulse ratio of the IPSC. 5-HT also decreased the frequency of miniature IPSCs without altering the amplitude. These data suggest that 5-HT presynaptically inhibited GABA release. Furthermore, 5-HT elicited a slow inward current in DCN neurons. Pharmacological studies showed that 5-HT activated the 5-HT(5) receptor, which is positively coupled to G protein and elicited the slow inward current through enhancement of hyperpolarization-activated cation channel activation. Finally, we examined the effects of 5-HT on the spike generation that accompanies repeti...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L MaroteauxR Hen
Feb 1, 1973·The Journal of Physiology·J C Eccles
Sep 1, 1995·Pflügers Archiv : European journal of physiology·P M LarkmanT Takahashi
Feb 22, 1994·The Journal of Comparative Neurology·P H Kitzman, G A Bishop
Nov 1, 1995·The European Journal of Neuroscience·C I De Zeeuw, A S Berrebi
May 29, 1998·Brain Research. Molecular Brain Research·M PasqualettiD Marazziti
Dec 29, 1998·European Journal of Pharmacology·B J FranckenJ E Leysen
Sep 9, 2000·Journal of Neurophysiology·M Ouardouz, B R Sastry
Dec 20, 2000·Brain Research·M Ito
Jan 12, 2001·Journal of Neurophysiology·D AnchisiF Tempia
Jun 27, 2002·Journal of Chemical Neuroanatomy·Frederik J GeurtsJean-Pierre Timmermans
Feb 8, 2003·Journal of Neurophysiology·Christine M Pedroarena, Cornelius Schwarz
Apr 11, 2003·Journal of Neurophysiology·Carlos D AizenmanDavid J Linden
Jul 23, 2003·Neuroscience Letters·Michela Di MauroFrancesca Santangelo
Jun 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·M SausbierP Ruth
Jun 24, 2004·European Journal of Pharmacology·David R ThomasPhilip D Hayes
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·Youssef Sari
Feb 18, 2005·Journal of Neurophysiology·Jayne R BramleyF Edward Dudek
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumihito SaitowShiro Konishi
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael L MolineuxRay W Turner
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei Zhang, David J Linden

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Citations

Apr 17, 2010·The Cerebellum·Reza TadayonnejadRay W Turner
Oct 23, 2013·Pflügers Archiv : European journal of physiology·Chang-Zheng ZhangJian-Jun Wang
Oct 5, 2011·The Journal of Physiology·Jordan D T EngbersRay W Turner
Jun 2, 2009·Biochemical Pharmacology·Zhihua Xie, Gregory M Miller
Sep 4, 2015·Cerebellum & Ataxias·Maryam Rahimi-BalaeiHassan Marzban
Jun 1, 2013·Neuroscience·M Oostland, J A van Hooft
Jul 11, 2016·Human Genetics·Murni TioEng-King Tan
Mar 17, 2017·Neuropharmacology·Moritoshi HironoShiro Konishi
Dec 26, 2019·Journal of Neurophysiology·Ryo YamamotoNobuo Kato
Jan 28, 2021·Chemistry : a European Journal·Simli DeySudipta Maiti
Jun 21, 2015·Journal of Cell Science·Katrin HolstEvgeni Ponimaskin
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Aug 24, 2021·Frontiers in Systems Neuroscience·Paolo FlaceGiuseppe Anastasi

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