Modulatory influences on antegrade and retrograde tonic reflexes in the colon and rectum

American Journal of Physiology. Gastrointestinal and Liver Physiology
Clinton NgAllison Malcolm

Abstract

Tonic reflexes in the colon and rectum are likely to be important in health and in disorders of gastrointestinal function. The aim of this study was to evaluate the fasting and postprandial "colorectal" and "rectocolic" reflexes in response to 2-min isobaric distensions of the colon and rectum, accounting for enteric sensation, compliance, and distending balloon volume. In 14 healthy fasting subjects, a dual barostat assembly was positioned (descending colon and rectum). A 2-min phasic distension was performed in the colon and rectum in random order while the opposing balloon volume was recorded. Sensation (phasic distension) and compliance (ramp distension) were also determined. The experiment was repeated postprandially. Colonic distension resulted in significant rectal tonic contraction in the fasting (rectal volume change: -35.4 +/- 8.4 ml, P < 0.01) and postprandial (-22.2 +/- 8.4 ml, P < 0.01) states. After adjustment for colonic sensitivity, for compliance, and for distending balloon volume, the rectal volume change remained significant; the extent of the tonic response, however, correlated significantly with increasing pain score (P < 0.01). In contrast, rectal distension did not produce a significant tonic response in ...Continue Reading

References

Oct 1, 1979·The Journal of Physiology·D L Kreulen, J H Szurszewski
Jun 1, 1991·Digestive Diseases and Sciences·S K Sarna
Aug 1, 1991·The American Journal of Physiology·J M RouillonJ R Malagelada
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Sep 2, 1998·The American Journal of Physiology·E S BjörnssonW L Hasler
Mar 10, 2000·The American Journal of Gastroenterology·A Malcolm, M Camilleri
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·A MalcolmA R Zinsmeister
Jul 8, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C E SlootsS G Meuwissen
Aug 22, 2001·The American Journal of Gastroenterology·Y K ChanJ E Kellow
Jun 14, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SteensA A M Masclee
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ngai-Moh LawAlan R Zinsmeister

❮ Previous
Next ❯

Citations

Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ji-Hong ChenJiande D Z Chen
Aug 12, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J Gunnarsson, M Simrén
Feb 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L Ohman, M Simrén
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P P J van der VeekA A M Masclee
Dec 23, 2008·The American Journal of Gastroenterology·Roel BakxGuy E E Boeckxstaens
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·V P SuttorA Malcolm
May 21, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Clinton NgAllison Malcolm
Mar 31, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·L ShimJ E Kellow
May 24, 2006·World Journal of Gastroenterology : WJG·Iris PosserudMagnus Simrén
Aug 17, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Dennis BourbeauKenneth Gustafson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Clinton NgAllison Malcolm
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
P P J van der VeekA A M Masclee
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
M CorsettiG Basilisco
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
C L KwanN E Diamant
© 2022 Meta ULC. All rights reserved