Modulatory role of cyclooxygenase-2 in cerebrovascular coupling

NeuroImage
Bojana StefanovicAfonso C Silva

Abstract

To investigate the role of cyclooxygenase-2 (COX-2) in the cerebrovascular coupling, hemodynamic and neuronal responses to forepaw stimulation were measured in alpha-chloralose-anesthetized rats (N = 18) before and after intravenous administration of Meloxicam (MEL), a preferential COX-2 inhibitor, and following a bolus of prostaglandin E(2) (PGE(2)), a prominent vasodilatatory product of COX-2 catalyzed metabolism of arachidonic acid. The cerebral blood flow (CBF) and blood-oxygenation-level-dependent (BOLD) response was quantified using continuous arterial spin labeling magnetic resonance imaging. Neuronal activity was measured by recording somatosensory-evoked potentials (SEPs) via intracranial electrodes. Both MEL and PGE(2) had a significant effect on the activation-elicited CBF (P < 10(-6)) and BOLD (P < 10(-6)) responses, without affecting the baseline perfusion. Meloxicam decreased brain COX enzymatic activity by 57 +/- 14% and decreased the stimulation-induced CBF response to 32 +/- 2% and BOLD to 46 +/- 1% of their respective pre-drug amplitudes. In turn, PGE(2) bolus resulted in a partial recovery of functional hyperemia, with the CBF response recovering to 52 +/- 3% and the BOLD response to 56 +/- 2% of their values...Continue Reading

References

Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ZhangA P Koretsky
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F WorleyJ M Baraban
May 1, 1995·The Journal of Comparative Neurology·C D BrederR P Kraig
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E ShimosegawaH Itoh
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Fabricius, M Lauritzen
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·W E KaufmannP Isakson
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D C Alsop, J A Detre
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Buxton, L R Frank
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C SilvaA P Koretsky
Jul 9, 1997·European Journal of Pharmacology·Y TaniguchiK Noda
Aug 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C SilvaA P Koretsky
Jun 1, 1997·NMR in Biomedicine·R W Cox, J S Hyde
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A C SilvaS G Kim
Aug 26, 1999·Life Sciences·A C HowlettW J Welsh
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A C SilvaS G Kim
Aug 8, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L J KemnaH Herzog
Dec 12, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Lauritzen
Jan 5, 2002·NeuroImage·K J WorsleyA C Evans
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Albert GjeddeManouchehr Vafaee
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Afonso C Silva, Alan P Koretsky
Apr 9, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Albert GjeddeLeif Ostergaard

❮ Previous
Next ❯

Citations

Dec 10, 2009·Neurochemical Research·Ho-Joo LeeAbesh Kumar Bhattacharjee
Jan 29, 2011·Acta Physiologica·C Lecrux, E Hamel
May 24, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoguang LiuRaymond C Koehler
Dec 27, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoguang LiuRaymond C Koehler
Jul 17, 2013·Current Opinion in Pharmacology·Elisabeth JonckersMarleen Verhoye
Jun 28, 2011·NeuroImage·Martijn E van RaaijBojana Stefanovic
Jun 27, 2009·Brain Research Reviews·Stanley I RapoportJagadeesh S Rao
Jan 24, 2009·Trends in Neurosciences·Raymond C KoehlerDavid R Harder
Dec 7, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bojana StefanovicAfonso C Silva
Sep 10, 2011·Neuron·Gabor C Petzold, Venkatesh N Murthy
Nov 23, 2013·Journal of the Neurological Sciences·Katalin SzaboLaszlo Olah
Apr 30, 2016·Journal of Neuroinflammation·Raffaella MorettiChristiane Charriaut-Marlangue
Oct 22, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Saba AidFrancesca Bosetti
Oct 2, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christoph LeithnerUte Lindauer
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Regina TiedeFrank Angenstein
Oct 25, 2008·Stroke; a Journal of Cerebral Circulation·Vikram JadhavTony Jer-Fu Lee
Oct 15, 2010·International Journal of Immunopathology and Pharmacology·S Delli PizziA Tartaro
Jul 15, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Akira Sumiyoshi, Ryuta Kawashima
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Grazia PerroneAntonio Scilimati
Aug 5, 2021·Journal of Neuroscience Research·Nafiseh GhazanfariErik F J de Vries
Nov 5, 2020·ACS Chemical Neuroscience·Navrinder KaurRamesh Chandra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Bojana StefanovicAfonso C Silva
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Xinqi PengRaymond C Koehler
Proceedings of the National Academy of Sciences of the United States of America
W E KaufmannP Isakson
© 2022 Meta ULC. All rights reserved