Modulatory role of glutamic acid on the electrical activities of pain-related neurons in the hippocampal CA3 region

Neuroscience Letters
Xu MaMan-Ying Xu

Abstract

Glutamic acid (Glu) participates in pain modulation of the central nervous system. The CA3 region of the hippocampal formation has been suggested to be involved in nociceptive perception. However, it is unknown whether Glu could modulate the electrical activities of pain-related neurons in the hippocampal CA3 region. The present study aimed to determine the effects of Glu and its receptor antagonist MK-801 in the pain-evoked response of both pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal CA3 region of normal rats. We used a train of electric impulses applied to the sciatic nerve as noxious stimulation. The electrical activities of either PENs or PINs in the hippocampal CA3 region were recorded by a glass microelectrode. The results revealed that intra-CA3 region microinjection of Glu (0.5 μg/1 μl) increased the evoked firing frequency and shortened the firing latency of PEN, while decreased the evoked firing frequency and prolonged the inhibitory duration of PIN in the hippocampal CA3 region of rat evoked by the noxious stimulation. Intra-CA3 region administration of MK-801 (0.25 μg/1 μl) produced the opposite response. These results suggest that Glu and its receptors in hippocampal CA3 region ...Continue Reading

References

Apr 1, 1992·Pain·John E McKenna, Ronald Melzack
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Aug 12, 2005·Journal of Neurochemistry·Terence J CoderreJonathan S C Yu
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May 14, 2008·Biochemical and Biophysical Research Communications·Ying ZhangManying Xu
Oct 16, 2008·Pharmacology, Biochemistry, and Behavior·André P SchmidtDiogo O Souza
Jan 13, 2009·Biochemical and Biophysical Research Communications·Runsheng JiaoXiaofang Yang
Apr 13, 2010·Biochemical and Biophysical Research Communications·Tie-feng ShiMan-ying Xu
May 5, 2011·Biochemical and Biophysical Research Communications·Minori KogaThomas W Sedlak

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