Modulatory role of glutathione monoester in augmenting age-associated neuronal antioxidant system

Experimental Aging Research
Ganesan Murali, Chinnakkannu Panneerselvam

Abstract

An ever-increasing number of reports show the involvement of free radicals in the functional and structural changes occurring in the brain as a part of the normal aging process. This study aimed to assess the potential efficacy of glutathione monoester (GME) when administered intraperitoneally (12 mg/kg body weight) for 20 days on memory and the antioxidant defense system and lipid peroxidation in discrete brain regions such as cortex, striatum, and hippocampus of young and aged rats. Age-associated decline in memory and activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione, vitamin E, and vitamin C, and elevated levels of lipid peroxidation and oxidized glutathione, were observed in all the brain regions studied (p < .001). GME administration was effective in restoring the antioxidant status and in decreasing lipid peroxidation level in aged rat brain regions.

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Citations

Jul 24, 2010·Antioxidants & Redox Signaling·Cynthia A Massaad, Eric Klann
Aug 18, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ganesan MuraliPeriannan Rasappan
Sep 1, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jiqu XuLiegang Liu
Feb 5, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ganesan MuraliChinnakkannu Panneerselvam
Jul 22, 2010·Glia·Jeff R LiddellGlenda M Bishop
Apr 23, 2014·Neurobiology of Learning and Memory·Yun-Zi LiuFu-Ming Shen

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