Modulatory role of miR-205 in angiogenesis and progression of thyroid cancer

Journal of Molecular Endocrinology
A SalajeghehA K Y Lam

Abstract

miR-205 plays a crucial role in angiogenesis and has been found in association with several types of cancers. The aims of this study were to investigate the clinical and functional roles of miR-205 on as the major initiator and modulator of angiogenesis in thyroid cancer. 101 thyroid carcinomas, including 51 conventional and 37 follicular variants of papillary thyroid carcinomas, and 13 undifferentiated thyroid carcinomas in addition to 13 lymph nodes with metastatic thyroid carcinoma were recruited to be compared with 14 nodular goitre and seven normal thyroid tissues. Five thyroid carcinoma cell lines, of papillary and undifferentiated origin with and without history of metastasis, were also used. Expression of vascular endothelial growth factor A (VEGFA) and miR-205 were measured and exogenous miR-205 were transfected to observe the changes of VEGFA (by immunofluorescence and western blot techniques). Proliferation assay, cell cycle analysis and apoptosis assays were also used to evaluate the role of miR-205 in these events. Significant under-expression of miR-205 and over-expression of VEGFA mRNA and protein were noticed in thyroid cancer tissues and cell lines compared to normal thyroid control. Transfection of miR-205 int...Continue Reading

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Citations

Oct 25, 2016·Experimental Cell Research·Vinod GopalanAlfred King-Yin Lam
Sep 1, 2016·Endocrine-related Cancer·Vincenzo MarottaAntongiulio Faggiano
Jan 11, 2018·Endocrine-related Cancer·Haleh VosghaAlfred King-Yin Lam
Oct 11, 2019·JCI Insight·John E McDonoughNaftali Kaminski
May 17, 2018·Molecular Medicine Reports·Yi GuTong Liu
Nov 5, 2017·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masoumeh AdhamiReza Malekpour Afshar
Dec 7, 2018·Journal of Cellular Biochemistry·Ozge Caglar, Akin Cayir
May 2, 2018·Frontiers in Endocrinology·Azliana Mohamad YusofNurul-Syakima Ab Mutalib
Nov 1, 2020·Cancers·Plabon Kumar DasAlfred K Lam
Apr 1, 2021·Hormones : International Journal of Endocrinology and Metabolism·Jie ZhouZhou Chen

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