Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin.

PloS One
Eduardo Martínez-MartínezGabriel Gutiérrez-Ospina

Abstract

The bulge region of the hair follicle contains resident epithelial stem cells (SCs) that are activated and mobilized during hair growth and after epidermal wounding. However, little is known about the signals that modulate these processes. Clinical and experimental observations show that a reduced supply of sensory innervation is associated with delayed wound healing. Since axon terminals of sensory neurons are among the components of the bulge SC niche, we investigated whether these neurons are involved in the activation and mobilization of the hair stem cells during wound healing. We used neonatal capsaicin treatment to reduce sensory terminals in the rat skin and performed morphometric analyses using design-based stereological methods. Epithelial proliferation was analyzed by quantifying the number of bromodeoxyuridine-labeled (BrdU(+)) nuclei in the epidermis and hair follicles. After wounding, the epidermis of capsaicin-treated rats presented fewer BrdU(+) nuclei than in control rats. To assess SC progeny migration, we employed a double labeling protocol with iododeoxyuridine and chlorodeoxyuridine (IdU(+)/CldU(+)). The proportion of double-labeled cells was similar in the hair follicles of both groups at 32 h postwounding...Continue Reading

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Mar 19, 2014·Journal of Dermatological Science·J ChéretC Le Gall-Ianotto
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Methods Mentioned

BETA
confocal microscopy
transgenic
histone acetylation
biopsy
Fluorescence

Software Mentioned

StereoInvestigator
Phothoshop

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