PMID: 2510126Oct 25, 1989Paper

Modulo, a new maternally expressed Drosophila gene encodes a DNA-binding protein with distinct acidic and basic regions

Nucleic Acids Research
E KrejciJ Pradel

Abstract

We have cloned, following an immunological screen of an expression library, five cDNA clones encoding the modulo antigen, a DNA-binding protein differentially expressed during Drosophila development. In addition a series of overlapping cDNA and genomic clones were also isolated. This protein is the product of a 2.2 kb mRNA that is encoded by a single genetic locus (100F). Analysis of the complete 544 amino-acid sequence, deduced from nucleotide sequence of cDNAs, shows that the polypeptide exhibits a primary structure with distinct charged regions, a modular structure found in several eukaryotic nuclear proteins, either transcription regulators or structural factors. The amino and carboxyl termini are rich in basic residues. The first third of the sequence contains a long domain comprised almost entirely of glutamic and aspartic acid residues. A typical cAMP dependent phosphorylation site and five potential glycosylation sites have been detected in the amino-acid sequence. Computer searches fail to reveal any significant homology with known proteins. Developmental pattern of transcription of the modulo gene indicates that messengers are maternally provided to the embryos and that zygotic transcription is required during subsequ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1978·FEBS Letters·F Sanger, A R Coulson
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J O'Kane, W J Gehring
Mar 11, 1988·Nucleic Acids Research·B Bellon
Sep 2, 1988·Science·R Schleif
Jan 1, 1986·Annual Review of Genetics·W J Gehring, Y Hiromi
Jun 5, 1987·Science·W J Gehring
Jan 1, 1987·Annual Review of Biochemistry·A M EdelmanE G Krebs
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M NolanT S Hsieh
Oct 6, 1988·Nature·I SadowskiM Ptashne
Oct 20, 1988·Nature·M Ptashne
Jun 5, 1987·Science·T ManiatisJ A Fischer
Oct 1, 1987·The Journal of Cell Biology·W C Earnshaw
Feb 1, 1980·Cell·E A FyrbergK L Kindle

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Citations

Feb 1, 1993·Trends in Genetics : TIG·C D ShafferS C Elgin
Jan 1, 1992·The Journal of Cell Biology·A PereiraL S Goldstein
Mar 30, 2007·Molecular Biology of the Cell·Zhengfang Cui, Patrick J DiMario
Apr 12, 2012·Molecular and Cellular Biology·José M AntãoRobert E Kingston
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Frédéric BantigniesSarah M Smolik
Mar 8, 2000·Mechanisms of Development·D J AndrewP Seshaiah
Sep 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Reuter, P Spierer

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