Modulus and direction of the neural current vector identify distinct functional connectivity modes between human MT+ areas

Journal of Neuroscience Methods
Masaki Maruyama, Andreas A Ioannides

Abstract

Reconstruction of neural current sources from magnetoencephalography (MEG) data provides two independent estimates of the instantaneous current modulus and its direction. Here, we explore how different information on the modulus and direction affects the inter-hemisphere connectivity of the human medial temporal complex (hMT+). Connectivity was quantified by mutual information values of paired time series of current moduli or directions, with the joint probability distribution estimated with an optimized Gaussian kernel. These time series were obtained from tomographic analysis of single-trial MEG responses to a visual motion stimulus. With a high-contrast stimulus, connectivity measures based on the modulus were relatively strong in the prestimulus period, continuing until 100 ms after stimulus onset. The strongest modulus connectivity was produced with a long lag (19 ms) of the right hMT+ after the left hMT+. On the other hand, connectivity measures based on direction were relatively strong after 100 ms, with a short delay of less than 6 ms. These results suggest that nonspecific and probably indirect communication between the homologous areas is turned, by the stimulus arrival, into more precise and direct communication thro...Continue Reading

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Citations

Jan 24, 2012·Vision Research·Sieu K Khuu, Shazaan Khambiye
Nov 29, 2012·NeuroImage·Sabrina PitzalisFrancesco Di Russo
Feb 11, 2015·NeuroImage·Janne KauttonenPia Tikka
Aug 5, 2014·Journal of Neuroscience Methods·Benoit R CottereauAnthony M Norcia

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