Abstract
Moebius sequence is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. It is questionable, whether there is a strong association of the sequence with autism spectrum disorders (ASDs) as suggested in some earlier case reports and studies. Twenty-two participants with Möbius sequence aged 6-16 years followed a request of the German Moebius foundation to participate in a nationwide study. All patients had a physical examination and intelligence testing. Primary caregivers were asked to complete two screening measures of ASD (Behaviour and Communication Questionnaire, VSK; Marburger Asperger's Syndrome Rating Scale, MBAS). For those who reached the cut-off for ASD and/or showed behavioural aspects indicative of ASDs during IQ testing and/or physical examination, well standardized diagnostic instruments (Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and Kinder-DIPS) were administered. Minimal diagnostic criteria for Möbius sequence were congenital facial weakness (uni- or bilateral) and impairment of ocular abduction (uni- or bilateral). Three boys (one of them mentally retarded) out of 22 participants (12 males and 10 females) were found...Continue Reading
References
Oct 1, 1989·Teratology·A H LipsonR A Osborn
Mar 1, 1989·Acta paediatrica Scandinavica·C Gillberg, S Steffenburg
Apr 1, 1986·American Journal of Medical Genetics·J N Bavinck, D D Weaver
Sep 1, 1972·Neurology·J R Miller, R E Myers
Oct 1, 1994·Journal of Autism and Developmental Disorders·C LordA Le Couteur
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S K BerumentA Bailey
Feb 27, 2001·American Journal of Medical Genetics·M L Martínez-FríasE Rodríguez-Pinilla
Jun 28, 2001·JAMA : the Journal of the American Medical Association·S Chakrabarti, E Fombonne
Sep 12, 2001·International Journal of Pediatric Otorhinolaryngology·L SjögreenC Jacobsson
Jun 14, 2003·Arquivos de neuro-psiquiatria·José Marcelino BandimAna Elizabeth Santos Costa
Aug 13, 2003·Neurology·Harriëtte T F M VerzijlGeorge W Padberg
Jan 24, 2004·Pediatric Neurology·Joseph M DooleyArawn Therrien
Jul 16, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Harvey B Sarnat
Feb 25, 2005·Journal of Neurology·H T F M VerzijlK P M van Spaendonck
Sep 1, 2005·Journal of Autism and Developmental Disorders·Dirk Kraijer, Annelies de Bildt
Aug 2, 2006·Clinical Genetics·W Briegel
May 2, 2007·Clinical Genetics·W Briegel
Mar 3, 2009·Child: Care, Health and Development·W BriegelE-M Knapp
Mar 4, 2009·European Child & Adolescent Psychiatry·Wolfgang BriegelK Otfried Schwab
Citations
Feb 28, 2016·Research in Developmental Disabilities·Linda Strobel, Gerolf Renner
Nov 19, 2011·Research in Developmental Disabilities·Wolfgang Briegel
May 8, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Dimitrios I ZafeiriouEuthymia Vargiami
Aug 30, 2011·Developmental Neurorehabilitation·Megan SipesNicole Turygin
Feb 13, 2016·Archives of Disease in Childhood·Victoria H McKayAdel Y Fattah
Jan 16, 2014·Journal of Health Psychology·Kathleen R Bogart
Jan 4, 2019·Genes, Brain, and Behavior·Elisa De StefaniPier Francesco Ferrari
Jul 2, 2019·The Journal of Craniofacial Surgery·Jose E Telich-TarribaAlexander Cardenas-Mejia
Nov 4, 2017·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Ahmed Mahrous, Ghadeer Thalji
Aug 6, 2020·International Journal of Environmental Research and Public Health·Matthew HottonLouise Dalton
May 17, 2019·Neural Plasticity·Ylenia NicoliniPier Francesco Ferrari
Jan 4, 2021·Muscle & Nerve·Tanya LehkyUNKNOWN Moebius Syndrome Research Consortium
Mar 2, 2021·Hand : Official Journal of the American Association for Hand Surgery·Jose E Telich-TarribaAlexander Cardenas-Mejia