Moebius sequence and autism spectrum disorders--less frequently associated than formerly thought

Research in Developmental Disabilities
Wolfgang BriegelInge Kamp-Becker

Abstract

Moebius sequence is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. It is questionable, whether there is a strong association of the sequence with autism spectrum disorders (ASDs) as suggested in some earlier case reports and studies. Twenty-two participants with Möbius sequence aged 6-16 years followed a request of the German Moebius foundation to participate in a nationwide study. All patients had a physical examination and intelligence testing. Primary caregivers were asked to complete two screening measures of ASD (Behaviour and Communication Questionnaire, VSK; Marburger Asperger's Syndrome Rating Scale, MBAS). For those who reached the cut-off for ASD and/or showed behavioural aspects indicative of ASDs during IQ testing and/or physical examination, well standardized diagnostic instruments (Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and Kinder-DIPS) were administered. Minimal diagnostic criteria for Möbius sequence were congenital facial weakness (uni- or bilateral) and impairment of ocular abduction (uni- or bilateral). Three boys (one of them mentally retarded) out of 22 participants (12 males and 10 females) were found...Continue Reading

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Citations

Nov 19, 2011·Research in Developmental Disabilities·Wolfgang Briegel
May 8, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Dimitrios I ZafeiriouEuthymia Vargiami
Feb 13, 2016·Archives of Disease in Childhood·Victoria H McKayAdel Y Fattah
Jan 16, 2014·Journal of Health Psychology·Kathleen R Bogart
Jan 4, 2019·Genes, Brain, and Behavior·Elisa De StefaniPier Francesco Ferrari
Jul 2, 2019·The Journal of Craniofacial Surgery·Jose E Telich-TarribaAlexander Cardenas-Mejia
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Aug 6, 2020·International Journal of Environmental Research and Public Health·Matthew HottonLouise Dalton
Jan 4, 2021·Muscle & Nerve·Tanya LehkyUNKNOWN Moebius Syndrome Research Consortium
Mar 2, 2021·Hand : Official Journal of the American Association for Hand Surgery·Jose E Telich-TarribaAlexander Cardenas-Mejia

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