Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
F Behnam RassouliZ Neshati

Abstract

Bladder cancer is the second common cancer of the genitourinary system throughout the world and intravesical chemotherapy is usually used to reduce tumour recurrence and progression. Human transitional cell carcinoma (TCC) is an epithelial-like adherent cell line originally established from primary bladder carcinoma. Here we report the effect of mogoltacin, a sesquiterpene coumarin from Ferula badrakema on TCC cells. Mogoltacin was isolated from the fruits of F. badrakema, using silica gel column chromatography and preparative thin layer chromatography. Mogoltacin did not have any significant cytotoxicity effect on neoplastic TCC cells at 16, 32, 64, 128, 200 and 600 microg ml(-1) concentrations. In order to analyse its combination effect, TCC cells were cultured in the presence of various combining concentrations of mogoltacin and vincristine. Cells were then observed for morphological changes (by light microscopy) and cytotoxicity using MTT assay. The effect of mogoltacin on vincristine toxicity was studied after 24, 48 and 72 h of drug administration. The results of MTT assay showed that mogoltacin can significantly enhance the cytotoxicity of vincristine and confirmed the morphological observations. Results revealed that co...Continue Reading

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Citations

Feb 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sara Soltanian, Maryam M Matin
Jul 16, 2010·Journal of Asian Natural Products Research·Samaneh MollazadehFatemeh Behnam-Rassouli
Oct 13, 2011·Natural Product Research·Vajiheh NeshatiMorvarid Saeinasab
Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Fereshteh HaghighiAzadeh Haghighitalab
Oct 15, 2013·Drug and Chemical Toxicology·Azadeh HaghighitalabHassan Porsa
Apr 5, 2011·Fitoterapia·Fatemeh Behnam RassouliAhmad Reza Bahrami
Oct 30, 2010·Phytotherapy Research : PTR·Zeinab Esmail Nazari, Mehrdad Iranshahi
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Maryam Moghaddam MatinFatemeh Behnam Rassouli
Dec 4, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Fatemeh Behnam RassouliFatemeh Kalalinia
Dec 7, 2010·Journal of Ethnopharmacology·Milad Iranshahy, Mehrdad Iranshahi
Dec 18, 2019·International Journal of Molecular Sciences·Lu ZhangZhibo Gai

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