Mohangic Acids A-E, p-Aminoacetophenonic Acids from a Marine-Mudflat-Derived Streptomyces sp

Journal of Natural Products
Munhyung BaeDong-Chan Oh

Abstract

Mohangic acids A-E (1-5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by (13)C NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity.

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Citations

Jan 15, 2020·Current Medicinal Chemistry·Dario MatuljaDean Marković
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Nov 13, 2018·Natural Product Research·Xiufang ZhangZhizhen Zhang
Jan 31, 2020·Frontiers in Chemistry·Kunlong LiHuaming Tao
Jul 26, 2019·The Journal of Organic Chemistry·Moritz SinastSabine Laschat

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