Mohs' micrographic surgery using frozen sections alone may be unsuitable for detecting single atypical melanocytes at the margins of melanoma in situ

The British Journal of Dermatology
R J BarlowN A Swanson

Abstract

It remains questionable whether micrographic surgery with frozen sections is an appropriate technique for excision of melanoma in situ (MIS) of the lentigo maligna type. Advocates of the technique have interpreted MIS as being histologically defined by nests and contiguous atypical melanocytes on the basal layer. Others, however, have viewed the periphery of MIS as consisting of scattered single atypical melanocytes, a finding that may be difficult or impossible to establish on frozen sections. To examine the reliability of micrographic surgery using frozen sections interpreted by an experienced Mohs' surgeon, in the excision of MIS. From a total of 154 specimens, frozen sections from the 50 specimens with margins that were considered difficult to interpret were thawed, sent for routine processing and then examined 'blind' by a dermatopathologist. Using the dermatopathologist's report on paraffin-embedded sections as a reference point, the sensitivity and specificity of frozen sections were calculated to be 59% and 81%, respectively. Using these histological criteria, micrographic surgery with frozen sections alone is unreliable in the excision of MIS.

References

Sep 9, 1992·JAMA : the Journal of the American Medical Association
Nov 1, 1991·Clinical and Experimental Dermatology·P CollinsW Manning
Dec 1, 1991·The American Journal of Dermatopathology·A B Ackerman, S Borghi
Jan 1, 1991·Journal of the American Academy of Dermatology·J A ZitelliE Abell
Dec 1, 1990·The Journal of Dermatologic Surgery and Oncology·F E MohsP O Larson
Jul 1, 1990·Archives of Dermatology·S S DhawanE Poulos
Nov 1, 1989·Journal of the American Academy of Dermatology·W MontagnaK Carlisle
Mar 1, 1987·The British Journal of Dermatology·M A Weinstock, A J Sober
Jun 1, 1986·The British Journal of Dermatology·D I McLean, K K Peter
Jun 1, 1986·Journal of the American Academy of Dermatology·K A Arndt
Mar 1, 1985·The Journal of Dermatologic Surgery and Oncology·F E Mohs
May 1, 1968·Cancer·D M Wayte, E B Helwig
Apr 1, 1967·American Journal of Surgery·J DavisG K Higgins
Mar 15, 1983·Cancer·R ShafirJ J Bubis
Oct 1, 1984·The Journal of Dermatologic Surgery and Oncology·S M BurgeR P Dawber
Apr 1, 1984·The American Journal of Dermatopathology·F PiscioliM Cristofolini
Jun 1, 1980·The Journal of Dermatologic Surgery and Oncology·W P ColemanE T Krementz
Jul 1, 1994·Journal of the American Academy of Dermatology·E G Kuflik, A A Gage
Jul 1, 1994·Journal of the American Academy of Dermatology·J K Robinson
Aug 1, 1994·The Journal of Dermatologic Surgery and Oncology·A B YountH T Greenway
Feb 1, 1993·The American Journal of Dermatopathology·A B Ackerman
Sep 1, 1996·British Journal of Plastic Surgery·D A de BerkerC M Lawrence
Dec 1, 1996·Journal of the American Academy of Dermatology·L M Cohen
Nov 21, 1997·Journal of the American Academy of Dermatology·T M JohnsonL Lowe

❮ Previous
Next ❯

Citations

Jul 21, 2004·Clinics in Dermatology·Joel Cook
Jun 2, 2010·The American Journal of Dermatopathology·L Frank GlassBasil S Cherpelis
Dec 3, 2009·Plastic and Reconstructive Surgery·Mark W BosbousMarcelle Neuburg
Oct 30, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Laura Chin-LennJohn P Arlette
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Peter R ShumakerHubert T Greenway
Jun 3, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Michael McLeodKeyvan Nouri
Sep 13, 2008·Annals of Surgical Oncology·Lynn DengelCraig L Slingluff
Sep 25, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Raj MallipeddiR Stan Taylor
May 10, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jeffrey K McKennaGlen M Bowen
Feb 12, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Natalie I BeneBrett M Coldiron
May 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sachin S BhardwajPeter K Lee
Dec 17, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Siew-Yin ThenDinesh Selva
Apr 14, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marianne Edwards DawnStanley J Miller
Jan 12, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Angela C S HutchesonJoel Cook
Oct 5, 2013·Annales de dermatologie et de vénéréologie·A LyJ-F Sei
Jul 18, 2012·Dermatologic Clinics·Andrea M HuiDaniel M Siegel
May 10, 2011·Clinics in Laboratory Medicine·Martin J Trotter
Mar 23, 2011·Dermatologic Clinics·Soon-You Kwon, Stanley J Miller
Feb 1, 2011·Seminars in Cutaneous Medicine and Surgery·Kristen L Toren, Eric C Parlette
Jun 15, 2010·Clinics in Dermatology·Ross M Levy, C William Hanke
Nov 3, 2009·Clinics in Dermatology·James Whalen, Douglas Leone
Sep 1, 2009·Surgical Pathology Clinics·Martin J Trotter
Jan 1, 2008·Advances in Dermatology·Brian L Baker, Scott W Fosko
Dec 15, 2015·Journal of Surgical Oncology·Cecilia G Ethun, Keith A Delman
Sep 18, 2007·Journal of the American Academy of Dermatology·Hobart W WallingRoger I Ceilley
Dec 13, 2005·International Journal of Dermatology·Carlos GarciaEduardo Poletti
Sep 15, 2004·Skinmed·Keyvan Nouri, Maria Patricia Rivas
Jan 16, 2004·Clinical and Experimental Dermatology·A M PowellR J Barlow
Aug 2, 2003·The British Journal of Dermatology·D J Eedy
Jun 11, 2010·International Journal of Dermatology·Corinne Erickson, Stanley J Miller
Jun 18, 2014·Clinical and Experimental Dermatology·A N PatelS Varma
Dec 15, 2005·Advances in Dermatology·Nathaniel J Jellinek
Jul 18, 2015·Journal of the American Academy of Dermatology·H William HigginsDavid J Leffell
Jul 31, 2016·Journal of the American Academy of Dermatology·Landon E StigallJohn A Zitelli
Aug 26, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·E DikaA Patrizi
Apr 6, 2004·Facial Plastic Surgery Clinics of North America·Ashley A SmithScott W Fosko
Aug 19, 2017·Plastic and Reconstructive Surgery·Kyeong-Tae LeeGoo-Hyun Mun
Mar 22, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Oleksandr TrofymenkoNathalie C Zeitouni
Apr 29, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·G PellacaniA Scope
Jan 23, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Julie ChampinThomas Alix
Jun 23, 2018·The Laryngoscope·Alexandra E QuimbyStephanie Johnson-Obaseki
Jul 31, 2014·F1000Research·Teresa TsakokRaj Mallipeddi

❮ Previous
Next ❯

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