Mold Infections in Solid Organ Transplant Recipients

Infectious Disease Clinics of North America
Tracy L Lemonovich

Abstract

Mold infections carry a substantial clinical and economic burden in solid organ transplant (SOT) recipients with a high overall mortality of near 30%. The most important pathogens include Aspergillus, the Zygomycetes, Fusarium, Scedosporium/Pseudallescheria, and the dematiaceous (dark) molds. Risk factors for the infections vary by transplant type but include degree of immune suppression and loss of skin or mucosal integrity. Correct diagnosis usually requires histopathology and/or culture. Management often requires a multidisciplinary team approach with combined antifungal and surgical therapies. This article reviews the epidemiology, risk factors, microbiology, diagnostic, and treatment approach to mold infections in SOT recipients.

Citations

Feb 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph J MackelChad Steele
Jul 22, 2020·The Cochrane Database of Systematic Reviews·Sandra K WhiteKimberly E Hanson

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