Molecular action mechanisms and membrane recognition of membrane-acting antimicrobial peptides

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
K Matsuzaki

Abstract

A number of antimicrobial peptides have been isolated in the animal kingdom, serving as defensive or offensive weapons. The mechanisms of their action are considered to be the permeability of bacterial membranes, although the details are not yet clarified. I have studied the interactions of several antibiotic peptides with both artificial lipid bilayers and biomembranes to elucidate the molecular mechanisms of the action and to find out the rationale for their membrane specificity. Magainin 2 from the Xenopus skin was found to form a peptide-lipid supramolecular complex pore in the membrane, followed by peptide internalization, simultaneously dissipating the transmembrane potential and the lipid asymmetry. This novel mechanism also works for a wasp bee venom, mastoparan X. Tachyplesin I from Tachypleus and a bee venom, melittin, also translocate across the membrane by forming a pore. The membrane selectivity of these peptides is closely related to their affinity for the lipids constituting the membrane surface. A strategy for developing a potent antibiotic was discussed based on these results.

Citations

Apr 21, 2019·Antibiotics·Rajesh KuppusamyNaresh Kumar
May 2, 2003·The American Journal of Chinese Medicine·Seok Hwa ChoiSok Cheon Pak

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