Molecular activation of NF-kappaB, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice

Biotechnology Letters
Young Mi HaHae Young Chung

Abstract

The effects of gamma-irradiation on inflammatory gene expression, including NF-kappaB activation, in the kidney of C57/BL6 mice exposed to 1-9 Gy doses of (60)Co gamma-irradiation. Radiation enhanced the NF-kappaB activation and oxidative stress caused a dose-dependent disruption in the redox balance. The significance of this study is the new molecular information gained on gamma-irradiation effects through the activation of pro-inflammatory genes by NF-kappaB via the MAPK signaling pathway. Considering the exquisite sensitivity of NF-kappaB and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress.

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Citations

Nov 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Nashwa H ZaherAmel F M Ismail
May 10, 2017·International Journal of Cancer. Journal International Du Cancer·Caroline JochemsJeffrey Schlom
Aug 10, 2016·Journal of Photochemistry and Photobiology. B, Biology·Marwa G El-GazzarAmel F M Ismail
Dec 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meejung AhnTaekyun Shin
Apr 26, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yang DengWei Mao

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