PMID: 8945966Nov 1, 1996Paper

Molecular activity of sodium pumps in endotherms and ectotherms

The American Journal of Physiology
Paul L ElseV Markus

Abstract

Previous research has shown ectotherms to have markedly lower sodium pump metabolism than endotherms. Direct measurement of enzymatic activity of the sodium pump (Na(+)-K(+)-adenosinetriphosphatase) confirmed this difference. To determine the source of this difference, sodium pump density was measured with the use of [3H]ouabain binding. Ectotherms and endotherms were found to share similar sodium pump numbers. Approximate densities (in pmol/g) were 250 for skeletal muscle, 500 for liver, 900 for heart, and 8,000 for kidney and brain. Therefore, differences in sodium pump activity between endotherms and ectotherms were due to differences in turnover rates or molecular activities of sodium pumps. Molecular activities of sodium pumps (in ATP/min) of tissues from endotherms were between 6,000 and 12,000 and, for ectotherms, between 1,500 and 2,500. Exceptions were found that included the heart of Bufo marinus. In a single invertebrate species studied, Charax destructor, the sodium pumps of the heart had a low molecular activity characteristic of ectothermic tissues. These results suggest that during the evolution of endothermy there was a general increase in the molecular activity of the sodium pump.

Citations

Jun 9, 2000·Annual Review of Physiology·A J Hulbert, P L Else
Jul 10, 2004·The Journal of Physiology·James A Fraser, Christopher L-H Huang
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Nigel TurnerPaul L Else
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J WuP L Else
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nigel TurnerPaul L Else
Dec 25, 2009·American Journal of Physiology. Cell Physiology·Monica L AcostaMichael Kalloniatis
Jul 21, 2009·The Journal of Experimental Biology·Isabel Walter, Frank Seebacher
Jun 11, 2003·The Journal of Experimental Biology·A J Hulbert
Apr 7, 2010·Biochimica Et Biophysica Acta·Raimund NoskeRonald J Clarke

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