Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration

Molecular Neurobiology
Christopher A BlackwoodJean Lud Cadet

Abstract

Repeated exposure to the opioid agonist, oxycodone, can lead to addiction. Here, we sought to identify potential neurobiological consequences of withdrawal from escalated and non-escalated oxycodone self-administration in rats. To reach these goals, we used short-access (ShA) (3 h) and long-access (LgA) (9 h) exposure to oxycodone self-administration followed by protracted forced abstinence. After 31 days of withdrawal, we quantified mRNA and protein levels of opioid receptors in the rat dorsal striatum and hippocampus. Rats in the LgA, but not the ShA, group exhibited escalation of oxycodone SA, with distinction of two behavioral phenotypes of relatively lower (LgA-L) and higher (LgA-H) oxycodone takers. Both LgA, but not ShA, phenotypes showed time-dependent increases in oxycodone seeking during the 31 days of forced abstinence. Rats from both LgA-L and LgA-H groups also exhibited decreased levels of striatal mu opioid receptor protein levels in comparison to saline and ShA rats. In contrast, mu opioid receptor mRNA expression was increased in the dorsal striatum of LgA-H rats. Moreover, hippocampal mu and kappa receptor protein levels were both increased in the LgA-H phenotype. Nevertheless, hippocampal mu receptor mRNA leve...Continue Reading

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Citations

Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ida FredrikssonYavin Shaham
Jun 23, 2020·Addiction Biology·Rachel D AltshulerXuan Li
Mar 13, 2020·Frontiers in Cell and Developmental Biology·Christopher A BlackwoodJean M Hébert
Dec 13, 2019·Addiction Biology·Hannah D FulenwiderJesse R Schank
Nov 24, 2020·Pharmacology, Biochemistry, and Behavior·Ewa Galaj, Zheng-Xiong Xi
Sep 16, 2019·Biological Psychiatry·Lola WelschBrigitte Lina Kieffer
Dec 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jerome A J BeckerJulie Le Merrer
Apr 9, 2021·Peptides·Richard J Bodnar

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Methods Mentioned

BETA
PCR

Software Mentioned

Image Lab
StatView
SPSS

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