Molecular Adaptations to Social Defeat Stress and Induced Depression in Mice

Molecular Neurobiology
Natalya BondarTatiana Merkulova

Abstract

Chronic stress is a risk factor for major depression. Social defeat stress is a well-validated murine model of depression. However, little is known about the gene activity dynamics during the development of a depression-like state. We analyzed the effects of social defeat stress of varying duration (10 and 30 days) on the behavioral patterns and prefrontal-cortex transcriptome of C57BL/6 mice. The 10-day exposure to social defeat stress resulted in a high level of social avoidance with no signs of depression-associated behavior. Most animals exposed to 30 days of social defeat stress demonstrated clear hallmarks of depression, including a higher level of social avoidance, increased immobility in the forced swimming test, and anhedonic behavior. The monitoring of transcriptome changes revealed widespread alterations in gene expression on the 10th day. Surprisingly, the expression of only a few genes were affected by the 30th day of stress, apparently due to a reversal of the majority of the early stress-induced changes to the original basal state. Moreover, we have found that glucocorticoid-sensitive genes are clearly stimulated targets on the 10th day of stress, but these genes stop responding to the elevated corticosterone lev...Continue Reading

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Citations

Jun 18, 2019·Developmental Psychobiology·Vasiliy V ReshetnikovNatalia P Bondar
Sep 8, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Benedikt Andreas GasserMarkus Georg Mohaupt
Oct 1, 2020·Cellular and Molecular Life Sciences : CMLS·Anne-Kathrin GellnerRené Hurlemann
Dec 22, 2020·Molecular and Cellular Neurosciences·Rosalina FonsecaCarla Simoes
Dec 18, 2020·Scientific Reports·Vasiliy V ReshetnikovNatalia P Bondar
Dec 18, 2020·Scientific Data·Tiziano FlatiTiziana Castrignanò
Jun 7, 2021·European Journal of Pharmacology·Xiao-Yuan JingLai-Fu Li

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Methods Mentioned

BETA
PCR
RNA-seq
ChIP-seq
GRBS
nucleotide
GTPases

Software Mentioned

Ensemble
Ensembl
Ethovision
GEne SeT AnaLysis Toolkit ( WebGestalt )
FastQC
STRING
BORIS
Trimmomatic
DESeq2
TopHat

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