Molecular allergy diagnostics refine characterization of children sensitized to dog dander

The Journal of Allergy and Clinical Immunology
Ulrika KäckJon R Konradsen

Abstract

Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs). Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive. There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% C...Continue Reading

Citations

May 15, 2019·Current Opinion in Allergy and Clinical Immunology·Yury ZhernovRudolf Valenta
Aug 14, 2020·Asia Pacific Allergy·Jeongmin LeeSooyoung Lee
Feb 13, 2020·Pulmonary Medicine·Andres SánchezJorge Sánchez
Jan 15, 2021·The Journal of Allergy and Clinical Immunology·Ann-Marie M SchoosMagnus P Borres
Nov 7, 2019·Current Opinion in Pediatrics·Sanny K Chan
Dec 8, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk
Mar 18, 2020·The World Allergy Organization Journal·UNKNOWN Steering Committee Authors, UNKNOWN Review Panel Members
Sep 4, 2020·Allergy·Öykü ÜzülmezHeimo Breiteneder
Apr 27, 2021·ERJ Open Research·Ulrika KäckJon R Konradsen
May 7, 2020·The World Allergy Organization Journal·Luis CaraballoAlexander Karaulov
Feb 13, 2019·The Journal of Allergy and Clinical Immunology·Ulrika KäckJon R Konradsen
Mar 10, 2019·The Journal of Allergy and Clinical Immunology·Paolo Maria MatricardiHarald Renz
Jun 13, 2021·International Journal of Immunopathology and Pharmacology·Natalia Ukleja-SokołowskaZbigniew Bartuzi
Jun 16, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Chrysanthi SkevakiUNKNOWN ALLIANCE Study Group
Aug 7, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jessica BagerAnna Asarnoj
Aug 15, 2019·International Archives of Allergy and Immunology·Gennaro LiccardiPaola Rogliani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
L MattssonJonas Lidholm
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L MattssonJonas Lidholm
International Archives of Allergy and Immunology
Anna AsarnojMagnus Wickman
Otolaryngologia polska. The Polish otolaryngology
Andrzej Emeryk, Małgorzata Bartkowiak-Emeryk
International Journal of Molecular and Cellular Medicine
Pasquale ComberiatiDiego Giampiero Peroni
© 2022 Meta ULC. All rights reserved